Zebrafish cancer

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We thank Frederic Rosa and Shuo Lin for access to their fish facilities, and Laure Bally-Cuif and Christof Leucht for the gift of the zebrafish line used for the Cre reporter experiments. This work has been supported by Association pour la Recherche sur le Cancer. PN research is supported in part by the National Science Foundation under Grant No. PHY05-51164. DKS acknowledges support from the NABI CNRS-Weizmann Institute program and DB the partial support of a PUF ENS-UCLA grant. 

Subsequent studies have demonstrated that zebrafish are sensitive to other carcinogens (e.g. DMBA and MNNG) from varying routes of exposure (e.g. refs. 18,161,162). These and similar studies have clearly demonstrated that although the zebrafish may not be as sensitive to carcinogen exposure as medaka or the rainbow trout (discussed below), it clearly is susceptible to cancer from exposure to environmentally relevant carcinogens. These studies are largely redundant with what has been previously accomplished with other fish models and they do not really exploit the novelty or wealth of available information from the zebrafish. 

Finally, it is clear that the use of zebrafish as a model for carcinogenesis studies is at its infancy. Nonetheless, as Amatruda et al.s recently observed The zebrafish system, with its combination of forward genetics and vertebrate biology, has great potential as a cancer model system. Currently, studies along these lines are underway at various laboratories around the world. 

Hisaoka KK (1958) The effects of 2-acetylaminofluorene on the embryonic development of the zebrafish II. Histochemical studies. Cancer Res 18 664-667... 

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