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Withania somnifera Withanolides

Jayaprakasam B, Zhang Y, Seeram NP, Nair MG (2003) Growth Inhibition of Human Tumor Cell Lines by Withanolides from Withania somnifera leaves. Life Sci 74 125... [Pg.412]

Sangwan, R., Chaurasiya, N.D., Lai, P, Misra, L., Tuli, R. and Sangwan, N. (2008) Withanolide A is inherently de novo biosynthesized in roots of the medicinal plant Ashwagandha (Withania somnifera). Physiol. Plant, 133, 278-87. [Pg.360]

Ray, S. and S. Jha (1999). Withanolide synthesis in cultures of Withania somnifera transformed with Agrobacterium tumefaciens. Plant Science Shannon. Aug. 146(1) 1-7. a Centre of Advanced Study, Department of Botany, University of Calcutta,... [Pg.164]

The withanolides are steroidal lactones built on an ergostane skeleton of 28 carbons functionalized at carbons 1, 22 and 26, commonly known as the withanolide skeleton. The first withanolide to be isolated and characterized was withaferin A, Fig. (1), isolated in 1965 almost simultaneously by Lavie from Withania somnifera and by Kupchan from... [Pg.1019]

Withanolide-containing plants are widely used for hair care. Datura metel, or Datura, is a widely recommended remedy for the treatment of dandruff. Withania somnifera, also known as ashwagandha or Indian ginseng, is the most widely used withanolide-containing plant in the Ayurvedic medicinal system for... [Pg.3476]

Kuroyanagi and his coworkers evaluated a series of sixteen withanolides, isolated from Withania somnifera, for their cell differentiation inducing ability and found that withaferin A (2), withanolide D (24), dihydrowithanolide D (59), and 27-hydroxywithanolide D (60) were potent cell differentiation inducers against the Ml cells [83]. It was further concluded that all these withanolides have a similar 4)S-hydroxy-5) -6)S-epoxy-2-ene-l-one moiety in ring A, apparently responsible for their cell differentiation inducing activity. [Pg.3481]

Choudhary MI, Yousuf S, Nawaz SA, Ahmed S, Atta-ur-Rahman (2004) Cholin- esterase inhibiting withanolides from Withania somnifera. Chem Pharm Bull 52(11) 1358-1381 Kirson I, Glotter E (1981) Recent developments in naturally occurring ergostane type steroids a review. J Nat Prod 44 633-647... [Pg.3489]

Kirson I, Glotter E, Lavie D (1971) Constituents of Withania somnifera Dun. Part XII. The withanolides of an Indian chemotype. J Chem Soc C 11 2032-2044... [Pg.3491]

Nittala SS, Lavie D (1981) Chemistry and genetics of withanolides in Withania somnifera hybrids. Phytochemistry 29 2741-2748... [Pg.3491]

Nittala SS, Vande VV, Lrolow F, Lavie D (1981) Chlorinated withanolides fiom Withania somnifera and Acnistus breviflorus. Phytochemistry 20 2547—2552... [Pg.3491]

Choudhary MI, Hussain S, Yousuf S, Dar A, Mudassar, Atta-ur-Rahman (2010) Chlorinated and diepoxy withanolides from Withania somnifera and their cyto- toxic effects against human lung cancer cell line. Phytochemitry 71(17-18) 2205-2209... [Pg.3492]

Malik F, Singh J, Khajuria A, Suri KA, Satti NK, Singh S, Kaul MK, Kumar A, Bhatia A, Qazi GN (2007) A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell mediated immune e responses by upregulation of Th 1 -dominant polarization in BALB/c-mice. Life Sci 80 1525—1538... [Pg.3494]

Zhao J, Nakamura N, Hattoii M, Kuboyama T, Tohda C, Kmnatsu K (2002) Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities. Chem Pharm Bull 50 760-765... [Pg.3494]

However, withaferin-A, which was the first active principle isolated from Withania somnifera and also constituted the first member of a new class of phytosteroids (the withanolides), produced immunosuppression. Thus, it inhibited adjuvant arthritis in rats, graft vs host reaction in chicken, xenograft vs host reaction in mice, and depleted murine splenic cells in vitro [38-41]. This effect has been attributed to the glucocorticoid-like structure of withaferin-A [39]. Withania somnifera also reduces acute phase reactants [8] as well as a2-macroglobulin during inflammation. [Pg.306]

Co-occurrence of lactol-type withasteroids and steroidal alkaloids/glycoalkaloids has been demonstrated in two Solamm spp. S. ciliatum, S. sisymbrifolium). However, there is no report on co-occurrence of these alkaloids and withanolides. In a few taxa even withanolides co-occur surprisingly with different types of tropane alkaloids, i.e., hyoscyamine-type tropanes fowDatura spp., Hyoscyamus niger) or non-hyoscyamine-type tropanes and related alkaloids Nicandra physalodes, Physalis alkekengi, P. peruviana, Withania somnifera) for details see Tables 3.1 and 3.8. [Pg.480]

Use of Withania somnifera as a valuable and very popular drug in Ayurvedic medicine (Ray and Gupta 1994) and Physalis alkekengi in Chinese medicine are two outstanding examples for an extensive significance of withanolide-containing... [Pg.480]

Five withanolides isolated from Withania somnifera [mdAjuga bracteosa Benth. (Lamiaceae)] were shown to be novel natural cholinesterase (AChE) inhibitors with spasmolytic and calcium antagonistic properties. Thus, they represent leads or even possible drug candidates for treatment of Alzheimer s disease or related dementia (Choudhary et al. 2004, 2005). Three withanolides were found to be linear mixed-type inhibitors of AChE, the remaining two were non-competitive inhibitors, whereas all... [Pg.482]

Abou-Douh AM (2002) New withanolides and other constituents from the fruits of Withania somnifera. Arch Pharm Pharm Med Chem 6 267-276 Abuijai T, Bemasconi S, Manzocchi L, Pelizzoni F (1996) Isolation of 7-dehydrocholesterol from cell cultures of Solarium malacoxylon. Phytochemistry 43 113-116 Abuijai T, Al-Khalil S, Abuirjeie M (1998) Vitamin Dj and its metabolites in tomato, potato, egg plant and zucchini leaves. Phytochemistry 49 2497-2499 Adam G, Chien NQ, Khoi NH (1981) Dunawithanin A and B, first plant withanoUde glycosides from Dunalia australis. Int Conf Chem Biotechnol Biol Act Nat Prod [Proc] 1st / 3. Bulg Acad Sci, Sofia, Bulgaria, pp 191-195... [Pg.496]

Matsuda H, Murakami T, Kishi A, Yoshikawa M (2001) Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera Dunal and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum. Bioorg Med Chem 9 1499-1507... [Pg.510]

Chemical studies on the leaf constituents of Acnistus arborescens [200], Withania somnifera [201-204], W. coagulens [205], and Jaborosa integrifoUa [206-208] have resulted in the discoveiy of the withanolides and jaboro-solides. One member of this group of steroidal lactones, withaferin A (L), has been found to be active against the experimental neoplasms W 256 and S 180. However, the therapeutic index of this compound is too small to warrant further pharmacological study [209]. [Pg.30]

See other pages where Withania somnifera Withanolides is mentioned: [Pg.11]    [Pg.11]    [Pg.51]    [Pg.53]    [Pg.380]    [Pg.408]    [Pg.347]    [Pg.288]    [Pg.521]    [Pg.143]    [Pg.316]    [Pg.704]    [Pg.728]    [Pg.2740]    [Pg.3467]    [Pg.3482]    [Pg.3485]    [Pg.4241]    [Pg.466]    [Pg.480]    [Pg.481]    [Pg.483]    [Pg.500]    [Pg.2786]    [Pg.2791]   


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Withania [Withanolides

Withania somnifera

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Withanolides

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