Neurite outgrowth activity

Sephel, G.C., Tashiro, K., Sasaki, M., Kandel, S., Yamada, Y. and Kleinman, H.K. (1989) A laminin-pepsin fragment with cell attachment and neurite outgrowth activity at distinct sites. Dev. Biol. 135 172-181. 

Zhao J, Nakamura N, Hattoii M, Kuboyama T, Tohda C, Kmnatsu K (2002) Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities. Chem Pharm Bull 50 760-765... 

Imagawa, H. Saijo, H. Yamaguchi, H. Maekawa, K. Kurisaki, T. Yamamoto, H. Nishizawa, M. Oda, M. Kabura, M. Nagahama, M. Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC 12 cells. Bioorg. Med. Chem. Lett. 2012,22, 2089-2093. 

Neovibsanins have been shown to display neurite outgrowth activity in PC12 cells, suggesting that neovibsanin-type compounds could be a candidate for the development of novel therapeutic agents to treat neurodegenerative diseases such as AD [43]. 

FIGURE 22 Quantitative assays for neurite outgrowth activities of acetal derivatives PC12 cells were cultured in two 24-well plates in DMEM+10% HS and 5% FBS for 24 h at a density of 2 X 10 cells/cm. Tlie medium was then changed to DMEM+2% HS and 1% FBS supplemented with NGF (10 ng/mL) in die absence or presence of test compound. After 4 days the length of the longest neurites were quantified. Data are expressed as the meaniSE (n=149). P<0.01 versus control Dunnett s/test... 

Furthermore, PKCe is required for nerve growth factor-induced activation of mitogen-activated protein kinases and neurite outgrowth by ethanol. It is also required for ethanol-induced increases in N-type voltage-gated calcium channels in PC 12 neural cells. 

Holmes TC, de Lacalle S, Su X et al (2000) Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc Natl Acad Sci 97 6728-6733... 

Ping L, Kimihiro M, Tohru Y, Yasushi O. Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PCI 2D cells. Dev Brain Res 2003 145 177-183. 

Santuccione, A., Sytnyk, V., Leshchyns ka, I., and Schachner, M. (2005) Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. J. Cell Biol. 169, 341-354. 

Nogo-A is a potent inhibitor of neurite growth and blocks axonal regeneration in the central nervous system. Early in vitro experiments showed that neurite outgrowth was impeded across a culture dish coated with CNS myelin whereas neurites would actively grow on a... 

Hundle B, McMahon T, Dadgar J, Messing RO (1995) Overexpression of epsilon-protein kinase C enhances nerve growth factor-induced phosphorylation of mitogen-activated protein kinases and neurite outgrowth. Biol Chem 270 30134-30140... 

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