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Water-soluble active ingredients

When a product contains more than one active ingredient, (including vitamin and/or trace element combinations), the dissolution rate of at lecist the least water soluble active ingredient (which should be a vitamin in the case of vitamin/ mineral combination products) should cilso be determined as a lot release requirement, unless otherwise determined by Council. [Pg.659]

Drugs, cosmetic ingredients, and food additives are microencapsulated for a variety of reasons, which include reducing local side-effects, controlled release, site-specific (drug) delivery, and drug targeting. A tremendous amount of research work has been done in a search for suitable methods to achieve an effective eneapsulation of water-soluble active matter. The physical characteristics of the microspheres produced largely determine their suitability for use for different objectives. Microspheres are prepared from both natural and synthetic polymers. [Pg.396]

The formulations of agrochemicals cover a wide range of systems which range from simple aqueous solutions (for water-soluble actives) and self-emulsifiable oils to disperse systems of suspensions, emulsions and microemulsions. More complex formulations such as multiple emulsions and suspoemulsions (mixtures of suspensions and emulsions) are also applied in some cases. Microencapsulation of active ingredients for controlled and sustained release represents a more sophisticated approach to the formulation of agrochemicals. Solid formulations of wettable powders, grains, granules and tablets are also used in many applications. [Pg.73]

The main purpose of pesticide formulation is to manufacture a product that has optimum biological efficiency, is convenient to use, and minimizes environmental impacts. The active ingredients are mixed with solvents, adjuvants (boosters), and fillers as necessary to achieve the desired formulation. The types of formulations include wettable powders, soluble concentrates, emulsion concentrates, oil-in-water emulsions, suspension concentrates, suspoemulsions, water-dispersible granules, dry granules, and controlled release, in which the active ingredient is released into the environment from a polymeric carrier, binder, absorbent, or encapsulant at a slow and effective rate. The formulation steps may generate air emissions, liquid effluents, and solid wastes. [Pg.70]

In the Phadebas TM amylase test (72) (Pharmacia Labs) the substrate was a water insoluble cross-TTnked blue starch in tablet form which also contains some inert ingredients, sodium and potassium phosphate buffer salts and sodium chloride. This polymer was hydrolyzed by amylase into water soluble blue starch fragments. After centrifugation the absorbance of the blue supernatant was proportional to the activity of amylase present in the test samples. The day to day variation on a quality control serum had a coefficient of variation of 2.7% based on 30 days of data in our laboratory. The method is simple, reproducible and uses microquantities of serum. [Pg.210]

Most injections are formulated as aqueous solutions, with Water for Injections BP as the vehicle. The formulation of injections depends upon several factors, namely the aqueous solubility of the active ingredient, the dose to be employed, thermal stability of the solution, the route of injection and whether the product is to be prepared as a multidose one (i.e. with a dose or doses removed on different occasions) or in a singledose form (as the term suggests, only one dose is contained in the injection). Nowadays, most injections are prepared as single-dose forms and this is mandatory for certain routes, e.g. spinal injections such as the intrathecal route and large-volume intravenous infusions (section 2.2). Multidose injections may require the inclusion of a suitable... [Pg.411]

Of the three organic phosphorus insecticides—hexaethyl tetraphosphate, tetraethyl pyrophosphate, and parathion—the first two have been shown to be mixtures (36) that contain tetraethyl pyrophosphate as the principal active ingredient. Several methods have been proposed for the determination of this compound in the commercial products (25, 35). All are based on the separation of the tetraethyl pyrophosphate from the related ethyl phosphates, followed by its hydrolysis to diethyl orthophosphoric acid and titration with standard alkali. Both hexaethyl tetraphosphate and tetraethyl pyrophosphate are soluble in water and are rapidly hydrolyzed to monoethyl and diethyl orthophosphoric acid. This rapid hydrolysis to nontoxic products greatly limits the duration of the in- secticidal effectiveness of tetraethyl pyrophosphate, but it also eliminates the danger of toxic residues on the crops treated. [Pg.69]

Trigard 75 WP is a new insecticide with a unique mode of action and a unique triazine structure. It is a solid formulated as a wettable powder and is packaged in water-soluble bags. The active ingredient in Trigard has the common name cyromazine. Cyromazine is a triazine, but, unlike the well-known triazine herbicides, this compound has insecticidal properties and no herbicidal activity. Cyromazine has low mammalian toxicity and low vapor pressure. It is hydrophilic, so dermal penetration is expected to be... [Pg.85]

The family Hamamelidaceae consists of 26 genera and about 100 species of shrubs or tress known to contain tannins and iridoids. The leaves are alternate, simple, and often palmately lobed. The flowers are small and appear in spikes. The fruits are woody, capsular, and scepticidal. In Western medicine, the dried leaves of Hamamelis virginiana (hamamelis, British Pharmaceutical Codex, 1963), yielding not less that 20% of alcohol (45%)-soluble extractive, have been used as astringents for the treatment of hemorrhoids. Hamamelis water (British Pharmaceutical Codex, 1969) made from the stems has been used as a cooling application to sprains and bruises and as a styptic remedy. It is also used in cosmetics and as active ingredient of eye lotions. [Pg.199]

Incorporation Amorphous 2. Active ingredient in water soluble polymer 8. Gelatine host for the chemicals 17. Use antifreeze gel to hold liquid AI in suspension (Good for controlling temperature and storage)... [Pg.425]

It is a yellow solid with a solubility in water of 0.007 mg/mL. The Tykerb tablet contains 405 mg of the active ingredient, and the inactives are magnesium stearate, microcrystalline cellulose, povidone, and sodium starch glycolate. [Pg.131]


See other pages where Water-soluble active ingredients is mentioned: [Pg.456]    [Pg.3744]    [Pg.155]    [Pg.805]    [Pg.121]    [Pg.122]    [Pg.805]    [Pg.9]    [Pg.995]    [Pg.430]    [Pg.434]    [Pg.456]    [Pg.3744]    [Pg.155]    [Pg.805]    [Pg.121]    [Pg.122]    [Pg.805]    [Pg.9]    [Pg.995]    [Pg.430]    [Pg.434]    [Pg.468]    [Pg.1777]    [Pg.300]    [Pg.8]    [Pg.298]    [Pg.196]    [Pg.291]    [Pg.74]    [Pg.535]    [Pg.720]    [Pg.1357]    [Pg.96]    [Pg.611]    [Pg.116]    [Pg.117]    [Pg.117]    [Pg.649]    [Pg.212]    [Pg.158]    [Pg.227]    [Pg.572]    [Pg.774]    [Pg.965]    [Pg.210]    [Pg.471]    [Pg.225]    [Pg.423]    [Pg.140]   
See also in sourсe #XX -- [ Pg.3744 ]




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Activity solubility

Ingredients, active

Water activation

Water active

Water activity

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