Formulations solids

Solvent-borne, Water-borne, and 100% Solids Formulations... 

It is suggested that, as a minimum routine for the final test of an alleged antibacterial semi-solid formulation, the following be used. 

The Maillard reaction is likely to take on additional significance with the introduction of many new protein and peptide pharmaceuticals. For example, Tarelli et al. have demonstrated that lysine vasopressin undergoes rapid glycation in the presence of reducing sugars in both aqueous and solid formulations and that the N-terminal adduct can form rapidly even at — 20°C [52], A textbook that deals with the consequences for the chemical and life sciences of the Maillard reaction has been published [53]. 

Trigard 75 WP is a new insecticide with a unique mode of action and a unique triazine structure. It is a solid formulated as a wettable powder and is packaged in water-soluble bags. The active ingredient in Trigard has the common name cyromazine. Cyromazine is a triazine, but, unlike the well-known triazine herbicides, this compound has insecticidal properties and no herbicidal activity. Cyromazine has low mammalian toxicity and low vapor pressure. It is hydrophilic, so dermal penetration is expected to be... 

Feed grain size, in potassium chloride compaction, 20 621—622 Feed handling, in pilot plants, 19 466-467 Feed industry, solid formulated enzymes in, 10 273 Feeding equipment... 

Determining whether absorption is related to the formulation or to an intrinsic property of the molecule can be obtained by comparing absorption from a solid formulation and an oral solution, ideally with an IV solution as a reference. 

Solid formulation mof low melting point of active ingredients... 

Solid formulation of low melting point active ingredients C. Da Cuhna, Z. Negus, J. Porter, A. Thawani... 

PROJECT 4 Solid Formulation of Low Melting Point Active Ingredient... 

The relatively sensible ideas are sorted into five categories. These include containment/package, encapsulation, incorporation, reaction/transportation and end concept. The ideas in italic are felt to be the most promising for the development of solid formulations of active ingredients. 

Table 13.3-1. Sorted Ideas for Solid Formulations of Active Ingredients...

A reciprocal proportionality exists between the square root of the characteristic flow rate, t/A, and the thickness of the effective hydrodynamic boundary layer, <5Hl- Moreover, f)HL depends on the diffusion coefficient D, characteristic length L, and kinematic viscosity v of the fluid. Based on Levich s convective diffusion theory the combination model ( Kombi-nations-Modell ) was derived to describe the dissolution of particles and solid formulations exposed to agitated systems [(10), Chapter 5.2]. In contrast to the rotating disc method, the combination model is intended to serve as an approximation describing the dissolution in hydrodynamic systems where the solid solvendum is not necessarily fixed but is likely to move within the dissolution medium. Introducing the term... 

We now turn briefly to the problem of peptide stability in the solid state [8] [88], First, we note that most - if not all - reactions discussed in the previous and subsequent sections can also occur in the solid state, although the kinetics and mechanisms of the reactions can be quite different from those observed in solution. Moisture content, the presence of excipients that act as catalysts, and surface phenomena are all factors whose roles are all-but-im-possible to predict. As a result, each formulation poses a new challenge to pharmaceutical scientists. As a rule, solution data cannot be used to predict the shelf-life of solid formulations, and extrapolating from one solid formulation to another can be misleading. 

For nonaqueous liquids and solid formulations (where the manufactured drug produet is the source of active ingredient), the beyond-use date is not later than 25% of the time remaining until the product s expiration date or 6 months, whichever is earlier. 

Pharmaceutical solids can generally be described as crystalline or amorphous (or glassy). In fact, the actual solid phase composition of a pharmaceutical formulation is usually characterized by an intermediate composition, both crystalline and amorphous in character. In a multicomponent system, such as a solid formulation comprising drug and excipient(s), certain components or even a single component may be... 

In 1974 Midwest Research Institute operated a pilot-scale multiple chamber incinerator to evaluate for EPA the operational variables for pesticide incineration (8). The system included a. pilot-scale incinerator, a three-stage scrubber system, and a scrubber water treatment system. Nine pesticides (aldrin, atrazine, captan, DDT, malathion, mirex, picloram, toxaphene, and zineb) in 15 liquid and solid formulations were studied. Destruction efficiencies generally exceeded 99.99% over a range of temperatures and retention times ( 950 to 1100°C, 1.2 to 6 s, and 80 to 160% excess air). This study also documented the generation of measurable quantities of cyanide in the incinerator off-gas during the incineration of organonitrogen pesticides. 

A dark green solid, formulated as Ba[Ru(0)2(0C0Me)4]-3H20, has been obtained by dissolving Ba[Ru(0)3(0H)2] in MeC02H/CH2Cl2. This compound is able to stoichiometrically... 

A diverse series of semi-solid formulations or vehicles exist and are normally employed for... 

Incendiary type warhead (with gelled formulations like Napalm and solid formulations based on pyrophoric metals)-used against fuel and ammunition dumps etc. 

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