Warburg effect

Stern, R. et al., Lactate stimulates fibroblast expression of hyaluronan and CD44 the Warburg effect revisited, Exp. Cell Res., 276, 24, 2002.. 

Unwin, R. D., Craven, R. A., Harnden, P., Hanrahan, S., Totty, N., Knowles, M., Eardley, I., Selby, P. )., Banks, R. E. (2003a). Proteomic changes in renal cancer and co-ordinates demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect. Proteomics 3, 1620-1632. 

Semenza, G.L. (2007b). HIF-1 mediates the Warburg effect in clear cell renal carcinoma. J. Bioenerg. Biomembr. 39 231-4. 

Kondoh, H. (2008). Cellular life span and the Warburg effect. Exp Cell Res 314(9), 1923-1928. 

Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kannagi R (2004) Hypoxia induces adhesion molecules on cancer cells a missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc Natl Acad Sci USA 101 8132-8137... 

Work on hydrazine sulfate by Joseph Gold, M.D., of the Syracuse Cancer Research Institute, Syracuse, New York, is said to be based on the Warburg effect (Moss, 1992, p. 316). The theory is that hydrazine sulfate cuts off the supplies of new glucose in the liver and thus starves the cancer and stops cachexia, the wasting away that accompanies cancer. 

Chesney, J. Mitchell, R. Benigni, F. Bacher, M. Spiegel, L. Al-Abed, Y. Han, J.H. Metz, C. Bucala, R. An inducible gene product for 6-phospho-fructo-2-kinase with an AU-rich instability element role in tumor cell glycolysis and the Warburg effect. Proc. Natl. Acad. Sci. USA, 96, 3047-3052 (1999)... 

Because of the HIF-la-dependent Warburg effect observed in tumors, inhibition of the glycolytic pathway, which has been proposed in the literature for decades [221], is an attractive therapeutic approach. Clinical studies in glioma patients have shown that administration of 2-deoxyglucose (2DG) was well tolerated in combination with radiotherapy [222]. In animal models, some groups have reported a synergy of 2DG with chemotherapy or radiation and... 

Robey IF, Stephen RM, Brown KS, Baggett BK, Gatenby RA, Gillies RJ. Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia 2008 10 745-756. 

The metabolites glutamine and glucose are the main substrates of mammalian cell culture. Nevertheless, even if they are not limited in oxygen, proliferating mammalian cells do not completely oxidize their main substrates to CO2 but produce the fermentative product lactate. This observation, termed Warburg effect, is hypothesized to be a result of the needs of proliferating cells for precursor metabolites instead of maximum ATP formation via complete... 

Vander Heiden, M.G., Cantley, L.C., and Thompson, C.B. (2009) Understanding the Warburg effect the metabolic requirements of cell proliferation. Science, 324, 1029-1033. 

Lu, H., Forbes, R.A., and Verma, A. 2002. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. The Journal of Biological Chemistry 277 23111-23115... 

P. Pedersen, Warburg, me and Hexokinase 2 Multiple discoveries of key molecular events underlying one of cancers most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen. J. Bioenerg. Biomembr., 39 (2007) 211-22. 

Lazova R, Chakraborty A, Pawelek JM. Leukocyte-cancer cell fusion initiator of the Warburg effect in malignancy. In Dittmar T, Zanker KS, editors. Cell fusion in health and disease. 11. Cell fusion in disease. Dordrecht Heidelberg London New York Springer Verlag 2011. p. 151-172. 

Vanda- Heiden MG, Cantley LC, Thompson CB. UndCTstanding the Warburg effect the metabolic requirements of cell prolifaation. Science. 2009 324(5930) 1029-33. doi 10. 1126/saence.1160809. 

R518 A. M. Weljie and F. R. Jirik, Hypoxia-Induced Metabolic Shifts in Cancer Cells Moving beyond the Warburg Effect , Int. J. Biochem. Cell Biol., 2011, 43, 981. 

Downstream effects of HIF activation include modulation of glycolysis capacity ( Warburg effect ), cell survival, and increased angiogenesis. 

WAGNER You made a careful distinction between the apparent Warburg effect for an electrolyte such as sodium, g-alumina or CuBr and the Warburg effect for Rb Ag4l5. Would you comment further on these differences in terms of mechan i sm[s) ... 

Cancer cells generally use glycolysis rather than respiration (oxidative phosphorylation) for energy (the Warburg effect), as a result of hypoxia that exists in tumors and damaged mitochondria. Usually dangerously damaged cells kill themselves via apoptosis, a mechanism of self-destruction that involves mitochondria, but this mechanism fails in cancer cells. 

Enhaneed glycolysis is observed in most of cancerous cells and tissues, called as the Warburg effect In colon and stomach cancer, tumor tissues contained nearly equal or higher amounts of glycolytic intermediates than their corresponding normal eounterparts, and this trend was clearer in colon tissues Methylglyoxal (MGO), a metabolite of the... 

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