E-selectin ligands

ESL-1 = E-.selectin-ligand-l M. Steegmaier, A. Levinowitz, S. Isenmann, E. Borges, M. Lenter, H. Kocher, B. Kleuser, D. Verstweber, Nature... 

An interesting contribution to the former strategy was made by Martens et al. [158], who screened recombinant peptide libraries to identify and optimize novel E-selectin ligands. 

Wild, M K, Huang, M.-C., Schulze-Horsel, U, van der Merwe, P A, Vestweber, D, Affinity, kinetics and thermodynamics of E-selectin binding to E-selectin ligand-1, J. Biol Chem., 276, 31602-31612, 2001. 

Fukuda, M N, Ohyama, C, Lowitz, K, Matsuo, O, Pasqualini, R, Ruoslahti, E, Fukuda, M, A peptide mimic of E-selectin ligand inhibits sialyl Lewis -dependent lung colonization of tumor cells. Cancer Res., 60, 450-456, 2000. 

Let us go back to the experiments which allowed the characterization of the E-selectin ligand (Section 17.6.2). Expressed in general terms, the applied... 

GlcNAc is indeed the minimum E-selectin ligand. The mucins of amniotic fluid... 

M. Rosch, H. Herzner, W. Dippold, M. Wild, D. Vestweber, and H. Kunz, Synthetic inhibitors of cell adhesion A glycopeptide from E-selectin ligand 1 (ESL-1) with the arabino sialyl Lewis structure, Angew. Chem. Int. Ed., 40 (2001) 3836-3839. 

C32H53NO28S 933.842 Component of Le type blood group substance. Potent E-selectin ligand, [ct] -19 (c, 1.42 in HjO) (as Na salt). 

Zollner O, Vestweber D. The E-selectin ligand-1 is selectively activated in Chinese hamster ovary cells by the alpha(l,3)-fucosyltransferases IV and VII. J. Biol. Chem. 1996 277 33002-33008. 

S. Goelz, R. Kumar, B. Potvin, S. Sundaram, M. Brickelmaier, P. Stanley, Differential expression of an E-selectin ligand (SLex) by two Chinese hamster ovary cell lines transfected with the same alpha (1,3)- fucosyltransferase gene (ELFT), J Biol Chem, (1994), 269, 1033-40. 

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