Fibroblast stimulation

It has been shown that glycolic acid has a kerat-olytic, germinative layer and a fibroblast stimulating action. 

Pierer M, Rethage J, Seibl R, et al. Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. J Immunol 2004 172(2) 1256-1265. 

SV-3T3 mice fibroblasts Stimulation of glucose uptake and degradation 27... 

Time and concentration dependence of glucose uptake and degradation by Simian virus modified (i.e. adipocyte-like) mice fibroblasts, stimulated by the galactosylpicolinato complex 10b (Figure 5.3).The ordinate indicates the absorption (in arbitrary units) in an MTT assay as a measure of the amount of glucose degraded in the cells after uptake. 

Ayusawa D, Shimizu K, Koyama H, Kaneda S, Takeishi K, Seno T (1986) CeU-cycle-directed regulation of thymidylate synthase messenger RNA in human diploid fibroblasts stimulated to proliferate. J Mol Biol 190 559-567... 

Fibroblasts-stimulating action Improvement in the coUagen fibers production Derma appears more dense Better quality of elastic fibers that appears longer, sharper, and less fragmented Improvement in the GAG physiological production (hyaluronic acid)... 

Bork, R. W., Svenson, K. L., Mehrabian, M., Lusis, A. J., Fogelman, A. M., and Edwards, P.A. (1992) Mechanisms controlling competence gene expression in murine fibroblasts stimulated with minimally modified LDL. Arterioscler. Thromb. 12,800-806. 

Tsai CH, Yang SF, Huang FM, Chang YC. The upregulation of cystatin C in human gingival fibroblasts stimulated with cyclosporine A. J Periodontal Res 2009 44(4) 459-64. 

Tsuboi, A., and Baserga, R., 1972, Synthesis of nuclear acidic proteins in density-inhibited fibroblasts stimulated to proliferate, /. Cell Physiol. 80 107. 

Non-crosslinked HA may also be used for skin biorevitalisation, a process of inducing fibroblast stimulation and regeneration of the intracellular components that support the dermis Biorevitalisation with HA is different from applications of HA as a filler. Although both procedures provide a reduction in skin wrinkles and folds biorevitalisation can also provide skin rehydration, treat skin irritation, reduce muscle tone of the face and neck, correct skin sagging of the abdomen, inner thighs and upper arms, reduce wrinkles around the eyes, chest and upper lip, as well as remove the dark circles around the eyes and shrink enlarged oily skin pores. This treatment provides reduction in skin wrinkles and dermal folds and is used for skin preparation prior to chemical peels or laser treatments [20-26]. 

Adamson lYR, Letoumeau HL, Bowden DH. Comparison of alveolar and interstitial macrophages in fibroblast stimulation after silica and long or short asbestos. Lab Invest 1991 64 339-344. 

---