Vascular systems reactive oxygen species

Darley-Usmar, V., Halliwell, B. (1996). Blood radicals reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharm. Res., 13(5), 649-662. 

Resveratrol can also prevent the initial events of atherosclerosis in endothelial cells by inhibition of the enzymatic systems producing reactive oxygen species, such as NADPH oxidase and hypoxanthine/xanthine oxidase, and by the inhibition of both the expression of adhesion molecules and the monocyte adhesion to endothelial cells [167]. Moreover, red wine polyphenols, in particular E-resveratrol, have been shown to inhibit the proliferation and the migration of vascular smooth muscle cells in intima, notably involved in the formation of atherosclerotic plaques [173]. In fact, resveratrol specifically blocks the mTOR pathway, which is activated by oxidized LDL, and regulates the proliferation of smooth muscle cells [174]. Other stilbenoids have been shown to exert an activity on this target as well. For example, pterostilbene inhibits vascular smooth muscle cell proliferation... 

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