L- Arginine-nitric oxide pathway

M.W. Radomski, R.M.J. Palmer, and S. Moncada, An L-arginine nitric-oxide pathway present in human platelets regulates aggregation. Proc. Natl. Acad. Sci. U.S.A. 87, 5193-5197 (1990). 

East, S. J., and Garthwaite, J. (1991). NMDA receptor activation in the rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway. Neurosci. Lett. 123, 17-19. 

Matheis, G., Sherman, M. P., Buckberg, G. D., Haybron, D. M., Young, H. H., and Ignarro, L. j. (1992). Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury. Am. J. Physiol. 262, H616-H620. 

Torrecilla, M., Ruiz-Ortega, J. A., Ugedo, L. Pineda, J. (2007). Excitatory regulation of noradrenergic neurons by L-arginine/nitric oxide pathway in the rat locus coeruleus in vivo. Naunyn Schmiedebergs Arch. Pharmacol., 375, 337-347. 

Radomski, M., and Moncada, S. (1991). Modulation of platelet aggregation by an L-arginine-nitric oxide pathway. Trends Pharmacol. Sci. 12, 87-88. 

Fleming, I., Gray, G., and Stoclet, J. C. (1993). Influence of endothelium on induction of the L-arginine Nitric oxide pathway in rat aortas. Am. J. Physiol. 264, H1200-H1207. 

Thiemermann, C. (1994). Role of the L-arginine-nitric oxide pathway in circulatory shock. Adv. Pharmacol. 28, 45-79. 

As yet, it has not been possible to pinpoint the exact site of injury to the L-arginine nitric oxide pathway. The defect may lie with the surface receptors, signal transduction, L-arginine deficiency, nitric oxide synthase, tolerance of smooth muscle, physical obstruction to the diffusion of nitric oxide by a thickened intima, or impaired guanylate cyclase activation. However, endogenous guanylate cyclase can be activated by exogenously administered nitric oxide to relax smooth muscle, even when unresponsive to acetyl-... 

Boger, R.H., Bode-Boger, S.M., and Frdlich, J.C. (1996) The L-Arginine-Nitric Oxide Pathway Role in Atherosclerosis and Therapeutic Implications, Atherosclerosis 127,1 11. 

The demonstration of the synthesis of nitric oxide fi-om the amino acid L-arginine by vascular endo-thehal cells has led to the elucidation of the importance of the L-arginine-nitric oxide pathway as a regulator of cell function in a number of tissues (Moncada et al. 1989). The reaction involves a 5-... 

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