Rabbit aorta

The 9,11-azo analog of PGH2, compound A, is stable indefinitely and is substantially more active than PGH2 in stimulating muscle contraction in the isolated rabbit aorta strip. 

Mechanical Response. At concentrations above 10 g/mL, MTX caused a sustained contraction in the rabbit aorta. The MTX-induced contraction lasted for at least 3... 

Figure 1. The log cx)ncentration-cx)ntractile response curves for maitotoxin (MTX) in the rabbit aorta in the presence ( ) or absence (o) of verapamil (10" M). Verapamil was administered 15 min before the application of MTX. The maximum response to MTX (3 x 10 g/mL) is expressed as 100%. Vertical lines indicate the standard error of mean (n=7). (Reproduced with permission from Ref. 13. Copyright 1983 Press Syndicate of the University of Cambridge)...

EC50 represents the drug concentration required to cause 50% of the respective maximal relaxation of rabbit aorta, independently from its extent From reference [70] From reference [148] See Fig. 8 From reference [149]... 

Minor, RL., Myers, P.R, Guerra, R, Bates, J.N. and Harrison, D.G. (1990). Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J. Clin. Invest. 86, 2109-2116. 

Andrews, Fi.E., Bruckdorfer, K.R., Dunn, R.C. and Jacobs, M. (1987). Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta. Nature (Lond.) 327, 237-239. 

FIGURE 1.23 Effect of a 10-min exposure to two concentrations of a phenoxybenzamine-like compound, dibenamine (DB), on the contractile response of a strip of rabbit aorta to adrenaline (epinephrine). (From Furchgott, R. F., Adv. Drug Res., 3, 21-55, 1966.)... 

The family of concentration-response curves in Figure 1.23 shows the effect of an alkylating agent on the contractile response of rabbit aorta to adrenaline. Note the reduction in the maximal response, the departure from parallelism, and the fact that the exposure times as well as the concentrations of the antagonist have been given for each curve. 

Vandelen, R.L., Arcuri, K.E., and Napier, M.A. (1985) Identification of a receptor for atrial natriuretic factor in rabbit aorta membranes by affinity cross-linking./. Biol. Chem. 260, 10889-10892. 

By acting on the vessel wall, estradiol significantly inhibited superoxide anion-induced vascular smooth muscle cell proliferation, whereas the pure antiestrogen ICI 164384 reversed the inhibitory effect of estradiol (Cathapermal et al. 1998). Fulvestrant also reversed the estradiol-induced increase in blood flow in rabbit aorta (Hegele-Hartung et al. 1997). 

Takeshima H, Komazaki S, Nishi M, lino M, Kangawa K 2000 Junctophilins A novel family of junctional membrane complex proteins. Mol Cell 6 11-22 van Breemen C, Farinas BR, Gerba P, McNaughton ED 1972 Excitation-contraction coupling in rabbit aorta studied by the lanthanum method for measuring cellular calcium influx. Circ Res 30 44-54... 

Thomas 1982) in monkeys. Isolated strips of aorta from rabbits, dogs, and ferrets were used to determine the effects of cyanide on vascular smooth muscle (Robinson et al. 1985b). Cyanide caused small contractions in the isolated rabbit aorta at low cyanide concentrations at higher cyanide concentrations, relaxation occurred. It was found that chlorpromazine or 4,4 -diisothiocyano-2,2 -stilbene disulfonic acid (DIDS) reduced the contractions (Robinson et al. 1985a). 

Robinson CP, Baskin SI, Franz DR. 1985a. The mechanisms of action of cyanide on the rabbit aorta. J Appl Toxicol 5 372-377. 

GaUe, J., Schneider, R., Heinloth, A., Dimmeler, S., and Heermeier, K., 1999, Lp(a) and LDL induce apoptosis in human endothelial cells and in rabbit aorta role of oxidative stress. Kidney Int. 55 1450-1461. 

Tanaka H, Sukhova GK, Swanson SJ, et al. Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury. Circulation 1993 88 1788-1803. 

Feverfew extract was shown to inhibit deposition, aggregate formation and spreading of platelets on collagen fibres [54]. Changes in membrane-cytoskeletal interaction leading to a change in expression of membrane receptors involved in these processes may explain this result. Feverfew extract was further able to protect the endothelial monolayer in rabbit aortas from perfusion injury and some reversible increase in cAMP levels in the aorta segments was found [55]. 

Ohizumi, Y. and Yasumoto, T., Contractile response of the rabbit aorta to maitotoxin, the most potent marine toxin, J. Physiol., 337, 711, 1983. 

Platelet and fibrin deposition are strongly influenced by plasma and cellular factors, by properties of the vessel wall and by flow, as shown experimentally with the model of the everted deendothelialised rabbit aorta, used by Baumgartner [9]. 

Matsunaga, K., and Furchgott, R. F. (1989). Interactions of light and sodium nitrite in producing relaxation in rabbit aorta. J. Pharmacol. Exp. Ther. 248, 687-695. 

Singer, H. A., and Peach, M. J. (1982). Calcium- and endothelium-mediated vascular smooth muscle relaxation in rabbit aorta. Hypertension (Dallas) 4, 11-19-11-25. 

Furchgott, R. F. (1988). Studies on relaxation of rabbit aorta by sodium nitrite The basis for the proposal that the acid-activatable factor from bovine retractor penis is inorganic nitrite and the endothelium-derived relaxing factor is nitric oxide. In Vasodilatation Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium (P. M. Vanhoutte, ed.), pp. 401-414. Raven, New York. 

Interestingly, the two diastereomers 18 and 19 are equipotent to All in binding to the ATj receptor. In a functional assay, using contraction of rabbit aorta rings, one of these diastereomers is a full agonist, but has approximately 300-fold less potency that All. Both diastereomers 20 and 21 were devoid of activity. 

No curarelike activity antagonized phenylephrine-induced rabbit aorta contraction transient blood pressure reduction in dogs 440... 

Curare-like activity, lowered blood pressure (dogs) antagonized phenylephrine-induced contractions of isolated rabbit aorta blocked neuromuscular transmission in rat hemidiaphragm preparation 440... 

Administration of papaverine along with trichloroisobutyl alcohol and acetylbromodiethylacetylurea increases the effect of the latter two substances (333). In mice, small doses of papaverine reduce the convulsive effect of procaine not however the lethal dose (334). Papaverine inhibits contractions of excised muscles induced by adenosine derivatives (335). j8-Phenylisopropylamine in relatively high concentration increases the tonus of the vascular musculature of the surviving isolated rabbit aorta. This effect was inhibited by papaverine (336). The effect of papaverine on respiration, blood pressure in dogs and cats, on isolated vessels, on the intestine in situ and in vitro as well as its toxicity in rats was not affected by Nalorphine (337). Premedication... 

Lau AK, Leichtweis SB, Hume P et al. Probucol promotes functional reendothelialization in balloon-injured rabbit aortas. Circulation 2003 107 2031-2036. 

Hiltunen et al, (20) have reported balloon catheter delivery of VEGF-C plasmid after angioplasty injury in vivo. They found a significant reduction in intima-media ratio of the vessels compared with controls. They also studied the effects of VEGF-A plasmid in the same model, but found no benefit. VEGF-D plasmid has also been infused into balloon-injured rabbit aortae. A nitric oxide-dependent significant reduction in intima/media ratio was observed at 14 days (21). 

Hiltunen MO, Laitinen M, Turunen MR et al. Intravascular adenovirus-mediated VEGF-C gene transfer reduces neoin-tima formation in balloon-denuded rabbit aorta. Circulation 2000 102( 18) 2262—2268. 

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