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Tumor protein

Rat oncomodulin, a parvalbumin-1 ike tumor protein that has two tyrosine residues but no tryptophan, exhibits fluorescence emission at 301 and 345 nm.(135) Upon binding two moles of Ca2+ per mole of oncomodulin, the 301-nm intensity increases while the 345-nm band decreases. These results were explained in terms of acidic side chains involved in either binding Ca2+ or accepting a proton on excited-state generation of tyrosinate. The cloned... [Pg.48]

A class of DUBs only identified since 2002 is the OTU (ovarian tumor protein) DUB class. The OTU domain was originally identified in an ovarian tumor protein from Drosophila mdanogaster, and over 100 proteins from organisms ranging from bacteria to humans are annotated as having an OTU domain. The members of this protein superfamily were annotated as cysteine proteases, but no specific function had been demonstrated for any of these proteins. The first hint of a role for OTU proteins in the ubiquitin pathway was afforded by the observation that an OTU-domain-containing protein, HSPC263, reacted with ubiquitin vinyl sulfone (an active-site-directed irreversible inhibitor of DUBs) [41]. [Pg.197]

Bhisutthibhan, J., Pan, X.-O., Hossler, P.A., Walker, D.J., Yowell, C.A., Carlton, J., Dame, J.B., and Meshnick, S.R. The plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin,. Biol. Chem., 273,16192,1998. [Pg.139]

Kale, A., Soylemez, F., and Ensari, A. 2001. Expressions of proliferation markers (Ki-67, proliferating cell nuclear antigen, and silver-staining nucleolar organizer regions) and of p53 tumor protein in gestational trophoblastic disease. Am. J. Obstet. Gynecol. 184 561—514. [Pg.324]

Gefitinib is a tyrosine kinase inhibitor that targets the tumor protein, epidermal growth factor receptor (EGFR), and was approved by FDA for advanced non-small cell lung cancer in May 2003. The overall response rate in the United States was about 10% (w = 216). A subset analysis revealed... [Pg.273]

Allen JG, Bourbeau MP, Wohlhieter GE et al (2009) Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J Med Chem 52 7044—7053... [Pg.49]

Wilms tumor protein-1 (WT-1) Nephroblastoma, mesothelioma, metanephric adenoma, ovarian serous carcinoma AML, desmoplastic small round cell tumor, endometrial stromal sarcoma, uterine leiomyosarcoma, granulosa cell tumor, thecoma, rhabdoid tumor Kidney, mesothelial cells, granulosa cells, Sertoli cells, fallopian tube endometrial stroma, spleen... [Pg.72]

Two vaccines for the treatment of multiple myeloma developed at the University of Arkansas for Medical Sciences are being prepared for phase III trials. Each vaccine contains peptide fragments from a tumor protein found on myeloma cells. [Pg.357]

Bhisutthibhan, J., Pan, X.-O., Hossler, P.A., Walker, D.J., Yowell, C.A., Carlton, J., Dame, J.B., and Meshnick, S.R. The plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin, /. Biol. Chem., 273,16192,1998. 21. Avery, M.A., Chong, W.K.M., and Jennings-White, C. Stereoselective total synthesis of (+)-artemisinin, the antimalarial constituent of Artemisia annua L., /. Am. Chem. Soc., 114,974,1992. Avery, M.A., Bonk, J.D., and Bupp, J. Radiolabeled antimalarials synthesis of 14C-artemisinin, /. Labelled Comp. Radiopharm., 38, 263, 1996. [Pg.132]

Gnanasekar M, K Ramaswamy. Translationally controlled tumor protein of Brugia malayi fimetions as an antioxidant protein. Parasitol Res 2007 101 1533-1540. [Pg.105]

Gnanasekar M, Rao KVN, Chen L et al. Molecular characterization of a calcium bindii translationally controlled tumor protein homologue fi ora the filarial parasites Brugia malayi and Wuchereria bancrofii. Mol Biochem Parasitol 2002 121 107-118. [Pg.107]

D-Amino acids have so far been shown to occur only in comparatively few compounds in nature but their distribution may be more widespread than appears at the moment. There is no evidence that any D-amino acids occur in proteins. The claims of Kogel with respect to tumor proteins have been critically discussed by several contributors to recent issues of Annwd Review of Biochemistry and it is not believed that a reiteration of contradictory findings and arguments could serve a useful purpose. [Pg.375]


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See also in sourсe #XX -- [ Pg.313 , Pg.315 ]




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Cell Division Activity, Errors in Function of Signal Proteins and Tumor Formation

Cellular retinoic acid-binding protein tumors, experimental

Human brain tumor cell proteins

Mitogen-activated protein kinase pathway, tumor suppressor activities

Ovarian tumor protein

Proteins tumor suppressers

Skin tumors proteins

Translationally controlled tumor protein

Tumor antigen proteins

Tumor cells protein turnover

Tumor growth, proteins that inhibit

Tumor markers proteins

Tumor suppressor protein

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