Human brain tumor cell proteins

Up to the present only two naturally-occurring N-hydroxypeptides have been isolated asparaginyl-L-a-N-hydroxyasparagine (46) (22) and aspartyl-L-a-N-hydroxyaspartyl-D-cycloserine (47) (23). The former was isolated from cultures of Mycobacterium avium, the latter (47) from Corynebacterium kutscheri. Both probably act as iron ionophores (siderophores) in these strains. It has also been reported (102) that in human brain tumor cell proteins one N-hydroxy amide bond occurs for every 300-500 amino acid residues. To date this has not been confirmed by other authors. 

Berger, W. et al. (2001) Overexpression of the human major vault protein in astrocytic brain tumor cells. International Journal of Cancer, 94 (3), 377—382. 

Pulliam L, West D, Haigwood N, Swanson RA (1993) HIV-1 envelope gpl20 alters astrocytes in human brain cultures. AIDS Res Hum Retroviruses 9 439 44 Pulliam L, Zhou M, Stubblebine M, Bitler CM (1998) Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor. J Neurosci Res 54 530-538... 

---