Tumor- genes

Ramaswamy, S., et al., "Multiclass Cancer Diagnosis Using Tumor Gene Expression Signatures," Proc. Natl. Acad. Sci. USA, 98, 15149-15154 (2001). 

In animal studies, mirex (a nonmutagenic hepatocarcinogen) promoted mouse skin squamous carcinomas and papillomas after initiation with 7,12-dimethyl-benz[a]anthracene (DMBA) for 1 week. Mirex, also, potentiated the promotional potency of the phorbol ester tumor promoter, 12-0 -tetradecanoylphorbol-13-acetate (TPA). There was a 90% incidence (activation) of the c-Ha-ras tumor gene in these co-promoted tumors. When both mirex and TPA gave a similar tumor yield, only the TPA response was associated with biochemical markers of enhanced cell proliferation, induction of epidermal ornithine decarboxylase activity and increased DNA synthesis, and hyperplasia. Thus, there is evidence for a dual effect of mirex during co-promotion first, as an independent tumor promoter with a mechanism different than that of phorbol esters and second, as a compound that also potentiates skin tumor promotion by TPA (Meyer et al. 1993, 1994 Moser et al. 1992, 1993). 

Y. Oka, O.A. Eiisseeva, A. Tsuboi, H. Ogawa, H. Tamaki, H. Li, Y. OJi, E.H. Kim, T. Soma, M. Asada, K. Ueda, E. Maruya, H. Saji, T. Kishimoto, K. Udaka, and H. Sugiyama, Human cytotoxic T iymphocyte responses specific for peptides of the wild-type Wilms tumor gene (WTl) product, Iininunogenetics 51, 99-107 (2000). 

Wifhouf a doubf, one of fhe mosf significanf fesfimonies to fhe power of fhe microarray has been in the characterization of cancer cell lines and tumor gene expression. The National Cancer Institute s (NCI) study of cDNA... 

Gene copy number — Tumors are known to contain variable numbers of genes relative to normal tissue. Comparison of the normal and tumor gene populations is useful in identifying tumors and their differentiated states. 

Advani S, Sibley GS, Song PY, et al. Enhancement of replication of genetically engineered Herpes Simplex Virus by ionizing radiation a new paradigm for destruction of intractable tumors. Gene Ther 1998 5 160-165. 

Ramaswamy S, Tamayo P, Rifkin R et al. Multiclass cancer diagnosis using tumor gene expression... 

Reddy, J.A., Abburi, C., Hofland, H., et al. (2002). Folate-targeted, cationic liposome-mediated gene transfer into disseminated peritoneal tumors. Gene ., 9(22), 1542-1550. 

McClatchey, A. I., Saotome, I., Mercer, K., Crowley, D., Gusella, J. R, Bronson, R. T. and Jacks, T. (1998). Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev. 12, 1121-1133. 

Sun, P. C., El-Mofty, S. K., Haughey, B. H. and Scholnick, S. B. (1995). Allelic loss in squamous cell carcinomas of the larynx discordance between primary and metastatic tumors. Genes Chromosomes Cancer 14, 145-148. 

Haber DA, Sohn RL, Buckler AJ, et al. Alternative splicing and genomic structure of the Wilms tumor gene WTl. PNAS USA 1991 88 9618-22. 

Ramaswamy S, Tamayo P, Rifkin R, Mukherjee S, Yeang CH, Angelo M, et al. Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A 2001 98 15149-54. 

Mundlos S et al (1993) Nuclear localization of the protein encoded by the Wilms tumor gene WT1 in embryonic and adult tissues. Development 119(4) 1329-1341... 

Brunelli, J.P., B.D. Robison and G.H. Thorgaard. Ancient and recent duplications of the rainbow trout Wilms tumor gene. Genome 44 455-462, 2001. 

Ueda T, Oji Y, Naka N, et al. Overexpression of the Wilms tumor gene WTl in human bone and soft tissue sarcomas. Cancer Sci. 2003 94 271-276. 

Shimizu M, Toki T, Takagi Y, et al. Immunohistochemical detection of the Wilms tumor gene (WTl) in epithelial ovarian tumors. Int J Gynecol Pathol. 2000 19 158-163. 

Waldstrom M, Grove A. Immunohistochemical expression of wilms tumor gene protein in different histologic subtypes of ovarian carcinomas. Arch Pathol Lab Med. 2005 129 85-88. 

Dupont J, Wang X, Marshall DS, et al. Wilms Tumor Gene (WTl) and p53 expression in endometrial carcinomas a smdy of 130 cases using a tissue microarray. Gynecol Oncol. 2004 94 449-455. 

Hashi A, Yuminamochi T, Murata S, et al. Wilms tumor gene immunoreactivity in primary serous carcinomas of the fallopian mbe, ovary, endometrium, and peritoneum. Int J Gynecol Pathol. 2003 22 374-377. 

Bergmann L, Maurer U, Weidmann E. Wilms tumor gene expression in acute myeloid leukemias. Leuk Lymphoma. 1997 25 435-443. 

Sugiyama H. Wilms tumor gene (WTl) as a new marker for the detection of minimal residual disease in letrkemia. Leuk Lymphoma. 1998 30 55-61. 

Hwang H, Quermeville L, Yaziji H, et al. Wilms tumor gene product Sensitive and contextually specific marker of serous carcinoma of ovarian surface epithelial origin. Appl Immunohistochem Mol Morphol. 2004 12 122-126. 

Stumpf E, Aalto Y, Hoog A, et al. Chromosomal alterations in human pancreatic endocrine tumors. Genes Chromosomes Cancer. 2000 29 83-87. 

Zhao J, Moch H, Scheidweiler AF, et al. Genomic imbalances in the progression of endocrine pancreatic tumors. Genes Chromosomes Cancer. 2001 32 364-372. 

Barnoud R, Delattre O, Peoc h M, et al. Desmoplastic small round cell tumor RT-PCR analysis and immunohistochemical detection of the Wilms tumor gene WTl. Pathol Res Pract. 1998 194 693-700. 

Biegel JA, Burk CD, Parmiter AH, Emanuel BS. Molecular analysis of a partial deletion of 22q in a central nervous system rhabdoid tumor. Genes Chromosomes Cancer. 1992 5 104-108. 

Schofield DE, Beckwith JB, Sklar J. Loss of heterozygosity at chromosome regions 22qll-12 and llpl5.5 in renal rhabdoid tumors. Genes Chromosomes Cancer. 1996 15 10-17. 

Uno K, Takita J, Yokomori K, et al. Aberrations of the hSNF5/ INIl gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors. Genes Chromosomes Cancer. 2002 34 33-41. 

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