Trolamine

Topical analgesics sometimes are used for mild pain or as an adjunct to systemic therapy. There are limited data to support the use of salicylate-containing rubefacients (e.g., methyl salicylate and trolamine salicylate) or other counterirritants (e.g., menthol, camphor, and methyl nicotinate) in OA.32 See Chap. 57 for more information on these products when used for musculoskeletal disorders. 

Trolamine salicylate 10-20% Aspercreme SportsCreme May increase INR with warfarin Little odor unless in combination product... 

Topical rubefacients containing methyl salicylate, trolamine salicylate,... 

Trade names for triethanolamine include Daltogen, Sterolamide, Sting-Kill, Thio-faco T-35, and Trolamine. 

Salicylates Muscle and joint pain in acute and chronic conditions (e.g., overuse injuries, rheumatoid arthritis] Aspirinlike drugs with analgesic and antiinflammatory effects (see Chapter 15] 10% trolamine salicylate ointment or 2°/o-3% sodium salicylate solution from negative pole 10% trolamine salicylate ointment or 3% sodium salicylate ointment... 

Synonym 2,2, 2"-nitrilotriethanol, 2,2, 2"-nitrilotrisethanol, triethylolamine, trihydroxytriethylamine, trolamine,... 

Topical mbefacients containing methyl salicylate, trolamine salicylate, and other salicylates may have modest, short-term efficacy for treating acute pain associated with OA. 

For pharmaceutical purposes, it is necessary to determine A-nitrosodietha-nolamine in trolamine. This compound is characterized by high volatility and low concentration in real samples. Thus, to determine trace amounts of this compound, preconcentration is needed. Vacuum distillation is one of the possible methods [81]. To quantitatively determine nitrosamines, GC and HPLC are often applied [82, 83]. According to the fifth European Pharmacopoeia, the maximum concentration of W-nitrosodiethanolamine should not exceed 25 ppb. 

SYNS DALTOGEN NITRILO-2,2, 2"-TRIETHANOL 2,2, 2"-NITRILOTRIETHANOL STEROLAMIDE THIOFACO T-35 TRIAETHANOLAMIN-NG TRIETHANOLAMIN TRIETHANOLAMINE (ACGIH) TRIETHYLOLAiNflNE TRI(HYDROXYETHYL)Ai nNE 2,2 ,2"-TRIHYDROXYTRIETHYLAMNE TRIS(2-HYDROXYETHYL)AMINE TROLAMINE... 

Ciccone, C.D. Leggin, B.Q. Callamaro, J.J. Effects of ultrasound and trolamine salicylate phonophoresis on delayed-onset muscle soreness. Phys. Ther. 1991, 71, 666-678. 

Anonymous. Trolamine concerns regarding potential carcinogenicity. WHO Drug Inf 1991 5 9. 

Trolamine polypeptide oleate-condensate (Cerumenex) Sulfonamides (Azulfidine, Bactrim) Clarithromycin (Biaxin) Amoxicillin and potassium clavulanate (Augmentin) Loracarbef (Lorabid)... 

Trolamine (triethanolamine salicylate, TEAS) is a salicylate derivative, which is also known as topical aspirin . It is an amino alcohol that is used for its topical analgesic and antiinflammatory properties. Like the better-known salicylate derivative, methyl salicylate - which has a rubefacient action used to good effect in sports injuries and rheumatism - TEAS is rapidly absorbed through normal skin after topical application. It is used widely for treating sunburn. 

Salicylate derivatives, especially trolamine, are applied to first- and second-degree burns. A first-degree burn consists... 

Trolamine must not be applied in cases of infection salicylates can accelerate the penetration of microbes into the skin and aggravate any pre-existing infection. It has been shown to cause local skin irritation and scabs to form on the areas to which it has been applied. Skin irritation increases the more it is applied. In smaller quantities, repeated application only induces epidermal hyperplasia. Some authors consider TEAS to be a potential cytotoxic agent. It is a potential skin irritant that makes the skin sensitive and can cause contact allergies. 

Trolamine is a salicylate derivative, and salicylic acid is a keratolytic agent that dissolves the intercorneocyte amorphous matrix and impairs the barrier function of the stratum corneum. 

Trolamine should therefore not be used during the immediate post peel period. 

The suppositories contain sulfanilamide 15.0% in a water-miscible, nonstaining base made from lactose, propylene glycol, stearic acid, diglycol stearate, methylparaben, propylparaben, trolamine, and water, buffered with lactic acid to an acid pH of approximately 4.3. Each suppository contains sulfanilamide 1.05 g with lactose in a base made from polyethylene glycol 400, polysorbate 80, polyethylene... 

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