Trolamine salicylate Warfarin

Trolamine salicylate 10-20% Aspercreme SportsCreme May increase INR with warfarin Little odor unless in combination product... 

Increased warfarin effects have been seen when methyl salicylate or trolamine salicylate were used on the skin. 

Methyl salicylate, in the form of gels, oil, or ointment applied to the skin, has been found to increase the effects of warfarin. Bleeding and bruising and/or raised INRs have been seen with both high " and low doses of methyl salicylate. One report described the possible additive effects of methyl salicylate oil (Kwan Loong Medicated Oil) and a decoction of Danshen (the root of Salvia miltiorrhiza) on the response to warfarin (see also Coumarins and related drugs + Herbal medicines Danshen (Salvia miltiorrhizay, p.415). A raised prothrombin time has also been reported with topical trolamine salicylate. ... 

Although the evidence is limited, it appears that topical methyl salicylate and trolamine salicylate can increase the effect of warfarin. 

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See also in sourсe #XX -- [ ]

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