Salicylate derivatives

The thermodynamic EM for the hydrolysis of the salicylate derivative is therefore favoured by a factor presumably similar to that which favours the hydrogen-bonded form of the salicylate anion. In terms of the dissociation constant of the phenol group, which is some 3 pAT units less acidic than expected for a phenol with an ortAo-carboxylate group (Eberson, 1969), a factor of 103, which is of the right order of magnitude to explain the observed effect, could be involved. 

MAGNESiUM SALiCYLATE A sodium free salicylate derivative that may have a low incidence of Gl upset. The product labeling and dosage are expressed as magnesium salicylate anhydrous. The possibility of magnesium toxicity exists in people with renal insufficiency. 

Brand Name(s) Tricosal, Trilisate Cfiemical Class Salicylate derivative... 

OTC Backache Pain Relief Extra Strength, Doan s Original, Extra Strength Doan s, Keygesic-10, Momentum Cfiemical Class Salicylate derivative... 

Chemical Class Salicylate derivative sulfonamide derivalive... 

Hauss, D.J., and H.Y. Ando. 1988. The influence of concentration of two salicylate derivatives on rectal insulin absorption enhancement. J Pharm Pharmacol 40 659. 

Thalamocortical radiation Salicylate Derivatives Ventrolateral nucleus of thalamus... 

Salicylamide gives a blue violet color with ferric chloride solution, a color reaction indicative to salicylate derivatives. 

Fig. 5. Time course of hydroxyl radical formation (i.e., salicylate-derived 2,5-DHBA) in mouse forebrain during the first 60 minutes after a moderately severe concussive head injury in male CF-1 mice. Values are the mean standard error for 10 animals at each time point. Asterisk indicates p < 0.05 vs uninjured mice by ANOVA. Reproduced with permission from ref. [55].

Dibenzo[/>, J]pvran-6-ones are formed by the Pd-catalysed cyclisation of aryl 2-iodobenzoates, whereas 2-iodobenzyl arylacetates afford 3-aryldihydroisocoumarins under the same conditions <07T10889>. The same dibenzopyranones are formed by way of a Suzuki cross coupling involving functionalised salicylates, derived from a formal [3+3] cyclisation between l,3-bis(silyl enol ethers) and 3-silyloxy-2-en-l-ones, and subsequent lactonisation (Scheme 32). In a variant route, the pre-lactonisation biaryl is derived from the bis(silyl enol ethers) and 3-aryl-3-silyloxyenones <07JOC6255>. 

As a result of this and Eq. 2.4, Hammett constants directly influence the complex formation eqnilibria, although to varying extents depending on whether this is first-order or second-order, the latter due to aromatic substitution next to different donor sites (P (phosphines), N (benzamides, pyridines or pyrazininm ions), S (thiophenolates) or O (phenolates, benzoates, combinations like salicylate derivates) or combinations thereof (see case c. above) (salen derivatives or those of hippnric acid, both linked to metal by N -t- O)). 

Morra P, Bartle WR, Walker SE, Lee SN, Bowles SK, Reeves RA. Serum concentrations of salicylic acid following topically applied salicylate derivatives. Ann Pharmacother 1996 30(9) 935-40. 

Intramolecular proton transfer in salicylic derivatives can be understood qualitatively considering the increased acidity of phenolic OH groups and the Increased basicity of carboxyl and carbonyl groups in the first excited singlet state (1,2). 

The H-bond strength of the third group—nonlumlnescent molecules—is similar to that of the salicylic derivatives, and no ground state tautomers are observed. Tremendous pK changes are necessary in order to facilitate proton transfer in the excited state. The deactivation path is still a matter of speculation. It is worth noting that a substance of the fluorescent class (phenyl salicylate, Table 2) has been the first ultraviolet stabilizer (9) used on a technical scale, despite its poor absorption intensity (screening effect). This substance is photo-chemlcally converted into 2,2 -dlhydroxy benzophenone (87) in a photo-Fries reaction. This can, however, not explain the total efficiency of this stabilizer (93). 

Acyclic and six-membered cyclic phosphorous acids, except salicylic derivatives, exist in a form containing the P(0)H fragment and have AHn values in the gaseous phase of —70 kJ mol", and values for 1,3,2-dioxophospholanic analogues are —40 kJ mol". Calorimetric studies, in a heat-flow reaction calorimeter on the reaction of dithiophosphoric acid 0,0 -dialkyl esters, (R0)2P(S)SH, with zinc oxide, have been used to determine the reaction kinetics, "... 

Trolamine (triethanolamine salicylate, TEAS) is a salicylate derivative, which is also known as topical aspirin . It is an amino alcohol that is used for its topical analgesic and antiinflammatory properties. Like the better-known salicylate derivative, methyl salicylate - which has a rubefacient action used to good effect in sports injuries and rheumatism - TEAS is rapidly absorbed through normal skin after topical application. It is used widely for treating sunburn. 

Various studies show that salicylate derivatives act as much through direct local diffusion as through absorption by the dermal blood vessels and redistribution of salicylates in the whole body. The blood level of salicylates increases in direct proportion to the quantity applied, the resorption surface and the number of topical applications. A large amoimt of salicylates can be absorbed through the skin. 

Salicylate derivatives, especially trolamine, are applied to first- and second-degree burns. A first-degree burn consists... 

Trolamine is a salicylate derivative, and salicylic acid is a keratolytic agent that dissolves the intercorneocyte amorphous matrix and impairs the barrier function of the stratum corneum. 

Symptoms of salicylism can appear with chemical peels when large amounts of salicylate derivatives are applied on the skin, on large surface areas or repeatedly, causing a high blood level of saKcylates. In cases of toxic levels of salicylate in the blood, an increase in oxygen consumption causes hyperthermia by the uncoupling of oxidative phosphorylation. 

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