Trolamine salicylate

Topical analgesics sometimes are used for mild pain or as an adjunct to systemic therapy. There are limited data to support the use of salicylate-containing rubefacients (e.g., methyl salicylate and trolamine salicylate) or other counterirritants (e.g., menthol, camphor, and methyl nicotinate) in OA.32 See Chap. 57 for more information on these products when used for musculoskeletal disorders. 

Trolamine salicylate 10-20% Aspercreme SportsCreme May increase INR with warfarin Little odor unless in combination product... 

Topical rubefacients containing methyl salicylate, trolamine salicylate,... 

Salicylates Muscle and joint pain in acute and chronic conditions (e.g., overuse injuries, rheumatoid arthritis] Aspirinlike drugs with analgesic and antiinflammatory effects (see Chapter 15] 10% trolamine salicylate ointment or 2°/o-3% sodium salicylate solution from negative pole 10% trolamine salicylate ointment or 3% sodium salicylate ointment... 

Topical mbefacients containing methyl salicylate, trolamine salicylate, and other salicylates may have modest, short-term efficacy for treating acute pain associated with OA. 

Ciccone, C.D. Leggin, B.Q. Callamaro, J.J. Effects of ultrasound and trolamine salicylate phonophoresis on delayed-onset muscle soreness. Phys. Ther. 1991, 71, 666-678. 

Increased warfarin effects have been seen when methyl salicylate or trolamine salicylate were used on the skin. 

Methyl salicylate, in the form of gels, oil, or ointment applied to the skin, has been found to increase the effects of warfarin. Bleeding and bruising and/or raised INRs have been seen with both high " and low doses of methyl salicylate. One report described the possible additive effects of methyl salicylate oil (Kwan Loong Medicated Oil) and a decoction of Danshen (the root of Salvia miltiorrhiza) on the response to warfarin (see also Coumarins and related drugs + Herbal medicines Danshen (Salvia miltiorrhizay, p.415). A raised prothrombin time has also been reported with topical trolamine salicylate. ... 

Methyl and trolamine salicylates possibly interact like high-dose aspirin , (p.385), because they are absorbed through the skin. ... 

Although the evidence is limited, it appears that topical methyl salicylate and trolamine salicylate can increase the effect of warfarin. 

CAS 2174-16-5 EINECS/ELINCS 218-531-3 Synonyms 2-Hydroxybenzoic acid, 2-[bis-(2-hydroxyethyl) amino] ethanol 2-Hydroxybenzoic acid, compd. with 2,2, 2"-nitrilotris [ethanol] (1 1) Salicylic acid, compd. with 2,2, 2"-nitrilotriethanol (1 1) Triethanolamine salicylate Trolamine salicylate... 

Chemical Structure methyl salicylate, see Figure 103.1 trolamine salicylate, see Figure 103.2... 

Salicylate can be applied to the skin as un-ionized salicylic acid (normally for its keratolytic activity), as a salicylate salt (most commonly trolamine salicylate), as esters such as methyl salicylate and, rarely, as aspirin. In the form most often used in topical products, salicylates work primarily as rubefacients. Rubefacients are compoimds that work by counter-irritation. 

In contrast, percutaneous absorption of a salicylate salt (i.e. trolamine salicylate) is only about 1%, and the concentrations in the dermis and subcutaneous tissue are much lower than after application of methyl salicylate. 

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