Tripelennamine

Chemical Name 4-Chloro-a-[4-[2-(diethylamino)ethoxy] phenyl] -a-(4-methylphenyl)ben-zene ethanol 

4-(/3-diethylaminoethoxy)-4-methylbenzophenone was prepared as follows a mixture of 200 g of 4-hydroxy-4-methylbenzophenone, 55 g of powdered sodium methoxide and 400 ml of ethanol was stirred for 30 minutes. A solution of 150 g of j3-diethylaminoethyl chloride in 300 ml of toluene was added and the mixture was refluxed four hours. The solvent was removed, the residue was taken up in ether, extracted with 5% NaOH solution, twice with water, the ether was removed and the residue was distilled. The product was obtained as an oil boiling at 232°C at 0.6 mm. 

1 liter of a 0.45N ethereal solution of p-chlorobenzyl magnesium chloride was added in 30 minutes to a stirred solution of 104 g (0.35 mol) of 4-(j3-diethylaminoethoxy)-4-methyl-benzophenone in 400 ml of dry ether. After stirring an additional hour, the mixture was decomposed by pouring onto 1 liter of cold 10% ammonium chloride solution, the ether solution was washed with water, and the ether was replaced with hot isopropanol containing a trace of ammonia. 1-[p-( 3-diethylaminoethoxy)phenyl]-1-phenyl-2-p-tolyl-2-p-chloroethanol separated as white crystals, melting at 104°Cto 106°C. 

Chemical Name N,N-dimethyl-N -(phenylmethyl)-N -2-pyridinyl-1,2-ethanediamine 

Trade Name Manufacturer Country Year introduced 

Chemical Name 4-Chloro-0 -[4-[2-(diethvlamino)ethoxv] phenyl] -Q -(4-methvlphenvl)ben-zene ethanol 

Chemical Abstracts Registry No. Trade Name 91-81-6 154-69-8 (Hydrochloride) Manufacturer Country Year Introduced  

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Another antitussive with weak antihistaminic activity is the Japanese compound picoperine [21755-66-8] (56). This compound is a stmctural isomer of the weU-known antihistamine tripelennamine and is more potent than codeine. The chemistry (79) and pharmacology (80) of picoperine have been reported. 

Tripelennamine as antihistamine, 1, 177 biological activity, 4, 911 toxicity, 4, 912 Tripelennamine, p-bromo-as antihistamine, 2, 520 a-Tripiperideine synthesis, 3, 510 Triprolidine... 

Amino-1,3-propanediol lopamidol 2-Aminopyrazine Sulfalene 2-Aminopyridine Diphenpyramide Methapyrilene HCI Phenyramidol Pyrilamine Sulfadiazine Tripelennamine Zolimidine... 

Warfarin sodium Benzal acetophenone Alkofanone Benzaldehyde Butalamlne HCI Chloramphenicol Fenipentol Isocarboxazid Oxacillin sodium Penicillin G benzathine Phenylpropanolamine HCI Tripelennamine Benzaldehyde cyanohydrin Ethotoin... 

C4H10CIN 107-99-3) see Bephenium hydroxynaphthoate Binedaline Brompheniramine Captodiame Carbinoxamine Chlorphenamine Chlorphenoxamine Cyclopentolate Dibenzepine Diltiazem Dimetindene Doxylamine Ethoheptazine Itopride hydrochloride Meclofenoxate Mepyramine Moxisylyte Normethadone Noxiptiline Pheniramine Phenyltoloxamine Tamoxifen Toremifene Trimethobenzamide Tripelennamine Zotepine... 

Intranasal corticosteroids are the most effective treatment for allergic rhinitis during pregnancy. Beclomethasone and budesonide have been used most. Nasal cromolyn and first-generation antihistamines (chlorpheniramine, tripelennamine, and hydroxyzine) are also considered first-line therapy. Loratadine and cetirizine have not been as extensively studied. 

Brompheniramine maleate Chlorpheniramine maleate Dexchlorpheniramine maleate Ethanolamine class, nonselective Carbinoxamine maleate Clemastine fumarate Diphenhydramine hydrochloride Ethylenediamine class, nonselective Pyrilamine maleate Tripelennamine hydrochloride Phenothiazine class, nonselective Promethazine hydrochloride Piperidine class, nonselective Cyproheptadine hydrochloride Phenindamine tartrate... 

Antihistamine drngs were discovered at the end of the 1930s. By 1950, highly effective histamine antagonists tripelennamine and diphenhydramine were synthesized, which triggered broad research in the area of synthesis of such drugs. 

Tripelennamine Tripelennamine, iV-benzyl-iV, Ai -dimethyl-iV-2-pyridylethylenediamine (16.1.6), is synthesized by reacting 2-benzylaminopyrridine (16.1.5) with 2-dimethy-laminoethylchloride in the presence of sodium amide. 2-Benzylaminopyrridine, in turn, can be easily synthesized by reduction of a Schiff base, synthesized by condensation of 2-aminopyrridine with benzaldehyde [9-11]. 

This drag lessens the allergic response of the organism caused by histamine. Tripelennamine is used for allergic symptoms, rhinitis, conjunctivitis, and for allergic and anaphylactic reactions. Synonyms of this drug are pelanin and pyribenzamine. 

Ts and Blues - Injection IV of oral preparations of pentazocine Talwin, Ts ) and tripelennamine (PBZ, Blues ), an H- -blocking antihistamine has become... 

Antihistamine Brompheniramine, cimetidine, methapheniline, methylthiouracil, mianserin, ranitidine, thenalidine, tripelennamine... 

The combination of pentazocine with the antihistamine tripelennamine results in a combination known to drug abusers as T s and blues. This combination produces heroinlike subjective effects, and heroin addicts use it in the absence of heroin. In addition, the use of pentazocine in combination with alcohol or barbiturates greatly enhances its sedative and respiratory depressant effects. 

B. Although scopolamine effectively combats motion sickness, it is an antimuscarinic agent, not an antihistamine. Dimenhydrinate is an antihistamine with signihcant antimuscarinic properties that are likely to contribute to its anti-motion sickness activity. Chlorpheniramine, fexofenadine, and tripelennamine are antihistamines without signihcant efficacy in the treatment of motion sickness. 

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