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Schiff’s base

Aldehydes undergo condensation with primary amines with the elimination of water to give compounds known as SchifF s Bases, which can also be used to characterise aldehydes. Benzaldehyde for example condenses readily with... [Pg.230]

Benzal derivatives. Primary aromatic amines generally condense directly with benzaldehyde to form benzal derivatives (Schiff s bases or anils) ... [Pg.653]

This is an example of the Doebner synthesis of quinoline-4-carboxylic acids (cinchoninic acids) the reaction consists in the condensation of an aromatic amine with pyruvic acid and an aldehj de. The mechanism is probably similar to that given for the Doebner-Miller sj nthesis of quinaldiiie (Section V,2), involving the intermediate formation of a dihydroquinoline derivative, which is subsequently dehydrogenated by the Schiff s base derived from the aromatic amine and aldehyde. [Pg.1010]

Several 2-phenyl-4-(substituted)arylthiazoles and Schiff s bases derived therefrom have been also reported (732). [Pg.193]

N substituted imines are sometimes called Schiff s bases after Hugo Schiff a German chemist who de scribed their formation in 1864... [Pg.724]

Reaction with primary amines (Section 17 10) Isolated product is an imine (Schiff s base) A carbinolamine inter mediate is formed which undergoes de hydration to an imine... [Pg.744]

Schiff s bases of etbyleneimine dimer are obtained from the reaction of aromatic aldehydes, eg, ben2aldehyde [100-52-7] or furfural [98-01-00] and ethyleneimine (228). [Pg.8]

The early chemistry leading to these derivatives was originally carried out via the 6a-(methylthio) derivative (17) which was prepared by way of a Schiff s base (39). The 6a-thiomethyl group could then be displaced by various nucleophiles giving rise to 6a-methoxy or other 6a-substituted penicillins. A stereo-specific one-step introduction of a methoxy group at C-6 in penicillins provided a simple entry to 6a-methoxy penicillins (40) in yields ranging from 50—62%. [Pg.79]

Pyridoxal Derivatives. Various aldehydes of pyridoxal (Table 3) react with hemoglobin at sites that can be somewhat controlled by the state of oxygenation (36,59). It is thereby possible to achieve derivatives having a wide range of functional properties. The reaction, shown for PLP in Figure 3, involves first the formation of a Schiff s base between the amino groups of hemoglobin and the aldehyde(s) of the pyridoxal compound, followed by reduction of the Schiff s base with sodium borohydride, to yield a covalendy-linked pyridoxyl derivative in the form of a secondary amine. [Pg.163]

Fig. 3. (a) Reaction of pytidoxal 5 -phosphate (PLP) witii an amino-temiinal amino group of hemoglobin (Hb). The reagent is in the form of a Schiff s base with tris(hydroxymethyl)aminomethane [77-86-1] (Tris) buffet, and the reaction is a transamination, (b) The resulting unstable Schiff s base is reduced with... [Pg.163]

An alternative method involves reaction of an a-acylaminoketone (12) with a primary amine and subsequent ring closure of the resultant Schiff s base (13) with phosphoryl chloride. This enables the introduction of a 1-substituent as in (14) to be carried out efficiently, and if the amine were replaced with a monosubstituted hydrazine, the imidazole derivative (IS) resulted (78LA1916). [Pg.114]

A similar treatment of the Schiff s base derived from 3-nitro-2-thienylcarbaldehyde (564) with triethyl phosphite gave the thieno[3,2-h]pyrazole (565) (78CC453). ... [Pg.164]

Macrocycles have been prepared by formation of macrocyclic imines as well as by using variations of the Williamson ether synthesis ". Typically, a diamine or dialdehyde is treated with its counterpart to yield the Schiff s base. The saturated macrocycle may then be obtained by simple reduction, using sodium borohydride, for example. The cyclization may be metal-ion templated. In the special case of the all-nitrogen macrd-cycle, 15, the condensation of diamine with glyoxal shown in Eq. (4.14), was unsuccess-ful ... [Pg.164]

Aromatic nitro compounds are often strongly colored. They frequently produce characteristic, colored, quinoid derivatives on reaction with alkali or compounds with reactive methylene groups. Reduction to primary aryl amines followed by diazotization and coupling with phenols yields azo dyestuffs. Aryl amines can also react with aldehydes with formation of Schiff s bases to yield azomethines. [Pg.66]

Apply sample solution, followed by 1% aniline in [107] dichloromethane and chromatograph the ScHiFF s bases after 10 mm... [Pg.76]

Sugars react with the reagent probably with the formation of Schiff s bases ... [Pg.154]

Aminodiphenyl reacts with carbonyl compounds to form colored or fluorescent Schiff s bases with the elimination of water ... [Pg.158]

Heating the sugar with strong acid yields furfural derivatives. Aldohexoses can eliminate water and formaldehyde under these conditions yielding furfural. This adehyde reacts with amines according to I to yield colored Schiff s bases. Ketohex-oses condense with diphenylamine in acid medium with simultaneous oxidation according to II to yield the condensation product shown. [Pg.180]

Heating the sugars with strong add yields furfural derivatives. Under these conditions aldohexoses can eliminate formaldehyde and water to yield furfural. This aldehyde reacts with amines to yield colored Schiff s bases. [Pg.185]

Vanillin reacts with primary amines in weakly basic media to form fluorescent or colored Schiff s bases whereby colored phenolates are also produced at the same time. [Pg.434]

This was confirmed by an independent analytical method by Spath and Boschan, and by a synthesis of pellotine by Spath and Becke, starting from the benzyl ether of 2-hydroxy-3 4-dimethoxyacetophenone, which was converted by aminoacetal into the Schiff s base (V). This, on treatment with sulphuric acid (73 per cent.), followed by warm water, gave 8-hydroxy-6 7-dimethoxy-l-methyh 5oquinoline (VI), of which the methiodide, m.p. 188-189-5°, on reduction furnishes pellotine (IV). From dZ-pellotine so formed Spath and Kesztler, by a special process of fractionation, isolated 1-pellotine having — 15-2° (CHCI3), for which... [Pg.158]

A synthesis of possible biological significance was effected by Spath and Berger, who ozonised eugenol methyl ether to 3 4-dimethoxyphenyl-acetaldehyde (Villa), which was then condensed with 3 4-dimethoxy-phenylethylamine (Vlllb), and the resulting Schiff s base (IX) treated wit hot 19 per cent, hydrochloric acid, whereby it was transformed into... [Pg.185]

Cotarnine resembles hydrastinine (p. 167) in its pharmacological effects, but Its action on the uterus is less marked. It does not constrict the arterioles and appears to have a depressant action on the heart. Magidson and Gorbovizki have shown 1 that the Schiff s bases formed by the condensation of aldehydes with 1-aminomethylanhydrocotarnine have a marked local anaesthetic action but are irritant. [Pg.211]

Secondar-y amines are prepared by hydrogenation of a carbonyl compound in the presence of a prirnar-y anine. An A-substituted imine, or Schiff s base, is an intermediate ... [Pg.934]

Schiff s base (Section 17.10) Another name for an imine a compound of the type R2C=NR. ... [Pg.1293]

Even 5,5-dimethyl-3-cyclohexylaminocyclohex-2-en-l-one (52), the mono-Schiff s base derived from the 1,3-diketone which is stable in the enamino ketone form (7) and theoretically could alkylate on nitrogen, gave the O-alkylated product (53) (23). [Pg.125]


See other pages where Schiff’s base is mentioned: [Pg.19]    [Pg.218]    [Pg.300]    [Pg.123]    [Pg.124]    [Pg.257]    [Pg.519]    [Pg.163]    [Pg.323]    [Pg.180]    [Pg.311]    [Pg.312]    [Pg.314]    [Pg.330]    [Pg.435]   
See also in sourсe #XX -- [ Pg.230 ]




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Alkylation of Schiff’s bases

Hydrolysis of a Schiff’s base

Reduction of Schiff’s base

Schiff bases s. Azomethines

Schiff s base compounds

Schiff s bases preparation

Schiff’s Base, Formation

Schiff’s base complexes

Schiff’s base with methyl anthranilate

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