Tripelennamine Alcohol

The combination of pentazocine with the antihistamine tripelennamine results in a combination known to drug abusers as T s and blues. This combination produces heroinlike subjective effects, and heroin addicts use it in the absence of heroin. In addition, the use of pentazocine in combination with alcohol or barbiturates greatly enhances its sedative and respiratory depressant effects. 

MAO inhibitors interfere with the detoxification of antihistamines and phenothiazines and thus prolong and intensify their central depressant and anticholinergic effects additive CNS depression and sedation may occur when tripelennamine is administered with other CNS depressants, such as alcohol, barbiturates, tranquilizers, sleeping aids, or antianxiety agents. 

Tertiary amines may also be synthesised by the alleviation of secondaiy amines with alcohols. Whereas the alkylation of primary amines involves formation of an imine intermediate, the alleviation of secondaiy amines requires the more challenging formation of an iminium ion intermediate prior to the return of hydrogen to the substrate. The pharmaceutical agents piribedil, tripelennamine, and chlorpheniramine were all prepared on milligram scale by [Ru(p-cymene)Cl2]2-catalysed iV-alkylation of secondary amines (Scheme 12.5). ... 

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