Tumours transplantable

N-(Phosphonoacetyl)-L-aspartic acid is of particular interest since it is a tumour inhibitor active against several transplantable tumours lung carcinomas and melanomas are very... 

In this connection it has been shown that the response of a range of transplanted tumours to a nitrogen mustard can be correlated with the ratio of free to protein-bound thiol content70. ... 

Table 3. The effect of different classes of anti-tumour agent on some transplanted tumours. The TLX5 (R) is a line with acquired resistance to a triazene and is cross resistant to BCNU. Triazenes and BCNU are active against tumours which do not respond to anti-metabolites and others that are insensitive to alkylating agents. The platinum complex was cis dichloro-bis(cyclopentylamine)platinum(II) and the triazene 5-(3,3-dimethyl-l-triazeno)-4-carbethoxy-2-me thy limidazole...

Warner JF, Dennert G (1982) Effects of a cloned ceU line with NK activity on bone marrow transplants, tumour development and metastasis in vivo. Nature 300 31-34... 

The effect of iron administration on induction of ferritin in a number of tissues and in a series of hepatic tumours has been studied by Linder (78, 144) and the increase in synthesis of ferritin following hepatectomy of rats carrying transplantable tumours has been examined (238). 

Many gold phosphine complexes have been found to be potent cytotoxic agents, to have antitumor activity against P388 leukaemia and to be active against a spectrum of transplantable tumour models . It has been of particular interest to obtain some of them labeUed with radioactive isotopes of gold and carbon for cellular, binding, metabolism and biodistribution studies. 

Watson, A. F. The chemical reducing capacity and vitamin C content of transplantable tumours of the rat and guinea pig. Br. J. Exp. Pathol.,... 

Exhibits activity against viral-induced, chemical-induced, and transplantable tumours. 

METHODS USED FOR DETECTING ANTITUMOUR ACTIVITY Transplantable tumours Spontaneous tumours Induced tumours Heteroplanted human tumours Tissue culture techniques Antimicrobial tests... 

A large number of transplantable tumour systems have been developed for detecting antitumour activity [5, 6]. These tests measure the effect of compounds on rapidly developing primary tumours produced by transplantation of experimental tumours in animals. More recently, attempts have been made to develop test systems capable of measuring the effect of compounds on metastases produced by the primary tumours [7]. 

Many attempts have been made to develop transplantable tumours as models for the study of specific human cancers. Thus, the Cloudman S91 melanoma was developed to select drugs for use in the treatment of human melanoma [9], and plasma cell tumours as models for multiple myeloma [10], The greatest disadvantage of this approach is that tumours tend to lose their special characteristics very rapidly during serial transplantation, with the result that the tumour obtained is similar to those originating from different tissues. An extension of this approach would be the matching of human cancers with transplantable tumours having similar enzyme content and other biochemical features. 

Mycophenolic acid is active against nine out of twenty transplanted tumours against which it has been tested [214-217]. It is active against several solid tumours in mice and rats, and increases the life span of mice bearing L 1210 by 166 per cent and 216 per cent when administered 250 and 500 mg/kg per day respectively. 

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