Gold phosphine complex

Hydroamination of olefins has received considerable attention this year as a route to functionalized piperidines and spiropiperidines, particularly in regard to the investigation of new catalysts. In the synthesis of spiro-piperidines, two new mild and more general intramolecular hydroamination protocols were developed this year. One protocol uses a cationic gold-phosphine complex (Au[P(fBu)2(o-biphenyl)]Cl) as the catalyst... 

Luminescence has been noted [88] in numerous gold phosphine complexes. 

TABLE 7. 31P NMR shifts41 and coordination chemical shifts for gold-phosphine complexes... 

One may conclude that Au5d orbitals should not be regarded as core, but rather as valence orbitals which contribute significantly to bonding in gold-phosphine complexes. 

A major hurdle towards understanding the unusual low temperature CO oxidation activities of supported Au catalysis is that there is a wide variation in the reported CO oxidation activities over these catalysts [5]. This arises because these catalysts are very sensitive to the preparation procedures. Most supported Au catalysts are prepared with the chloride-containing chloroauric acid precursor, although there have been recent attempts to prepare these catalysts with precursors such as dimethyl gold acetonate [6], gold-phosphine complexes [7], and gold ethylene diamine complexes [8]. This discussion will focus on the complications that arise with chloride-containing precursors. 

Many gold phosphine complexes have been found to be potent cytotoxic agents, to have antitumor activity against P388 leukaemia and to be active against a spectrum of transplantable tumour models . It has been of particular interest to obtain some of them labeUed with radioactive isotopes of gold and carbon for cellular, binding, metabolism and biodistribution studies. 

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