Translational control

Glucose transport activity is regulated through transcriptional and translational control of the GLUT proteins, through their activity, and through alterations of their intracellular distribution. Most importantly, the GLUT4 continuously cycles between an intracellular,... 

The Human Heat Shock Response Translational Control of the Heat Shock Response... 

Storti, R.V., Scott, M.P., Rich, A. Pardue, M.L. (1980). Translational control of protein synthesis in response to heat shock in D. melanogaster cells. Cell, 22,825-34. 

Comerford I, Nibbs RJ. Post-translational control of chemokines a role for decoy receptors Immunol Lett 2005 96(2) 163-174. 

Mathews MB, Sonenberg N, Flershey JWB (2007) Translational control in biology and medicine. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York... 

In 1976, Hamish Munro proposed a model for the translational control of ferritin synthesis (Zahringer et al., 1976), which not only represents a crucial and remarkably far-sighted contribution to our understanding of cellular iron metabolism, but also in the more general context of the posttranscriptional control of gene expression. 

Pavitt, G. D. (2005). eIF2B, a mediator of general and gene-specific translational control. Biochem. Soc. Trans. 33, 1487—1492. 

Donahue, T. (2000). Genetic approaches to translation initiation in Saccharomyces cerevisiae. In Translational Control of Gene Expression (N. Sonenberg, J. W. B. Hershey, and M. B. Mathews, eds.), pp. 487—502. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 

Campbell, S. G., Hoyle, N. P., and Ashe, M. P. (2005). Dynamic cycling ofeIF2 through a large eIF2B-containing cytoplasmic body Implications for translation control. J. Cell Biol. 170, 925-934. 

Scheuner, D., Song, B., McEwen, E., Liu, C., Laybutt, R., Gillespie, P., Saunders, T., Bonner-Weir, S., and Kaufman, R. J. (2001). Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol. Cell 7, 1165—1176. 

Preiss, T., Muckenthaler, M., and Hentze, M. W. (1998). Poly(A)-tail-promoted translation in yeast Implications for translational control. RNA 4, 1321-1331. 

DeFatta, R., Li, Y., and De Benedetti, A. (2002). Selective killing of cancer cells based on translational control of a suicide gene. Cancer Gene Ther. 9, 573-578. 

Polunovsky, V. A., Rosenwald, I. B., Tan, A. T., White, J., Chiang, L., Sonenberg, N., and Bitterman, P. B. (1996). Translational control of programmed cell death Eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc. Mol. Cell Biol. 16, 6573-6581. 

Regulation of catalase expression in eukaryotes takes place as part of a generalized response mechanism. In yeast, promoter elements of the peroxisomal catalase CTA-1 respond to glucose repression and activation by fatty acids as part of organelle synthesis. The cytosolic catalase CTT-1 responds as part of a generalized stress response to starvation, heat, high osmolarity, and H2O2, and there is even evidence of translational control mediated by heme availability 26). 

Despite the fluctuations in p27 protein levels during the cell cycle, the amount of p27 mRNA remains unchanged. Instead, p27 protein levels are regulated through translational controls (Hengst and Reed, 1996 Millard et... 

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