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Recombinant transgenic animals

Recombinant— transgenic animals and plants Low raw-material costs unlimited scaleup purification may be relatively easy Costly development and production unnatural sequences not possible... [Pg.33]

Biotechnology is being appHed in the dairy industry. A significant and controversial development is the technique of producing transgenic animals, ie, animals in which hereditary deoxyribonucleic acid (DNA) has been augmented by DNA from another source, using recombinant DNA (rDNA) techniques. [Pg.371]

More recently, recombinant antibodies (mostly IgGs) have been produced in the milk of transgenic animals [21,22]. In particular, one study with transgenic mice has shown that it is possible to produce a porcine chimeric IgA that can form dimers in the presence of the J chain [23]. However, the production of fully assembled slgA has yet to be reported. [Pg.163]

In addition to milk, a range of recombinant proteins have been expressed in various other targeted tissues/fluids of transgenic animals. Antibodies and other proteins have been produced in the blood of transgenic pigs and rabbits. This mode of production, however, is unlikely to be pursued industrially for a number of reasons ... [Pg.115]

Therapeutic proteins have also been successfully expressed in the urine and seminal fluid of various transgenic animals. Again, issues of sample collection, volume of collected fluid and the appropriateness of these systems render unlikely their industrial-scale adoption. One system that does show industrial promise, however, is the targeted production of recombinant proteins in the egg white of transgenic birds. Targeted production is achieved by choice of an appropriate... [Pg.115]

Uses of cloned genes Produce recombinant proteins Gene therapy (somatic) Transgenic animals (germ line) Produce cDNA probes for blots... [Pg.89]

The most recent twist in the use of recombinant DNA technology to produce drugs has been the development of transgenic plants with many of the capabilities of transgenic animals. Some authorities refer to this field of research as molecular farming and call the products of their research farmaceuticals. [Pg.76]

Transgenic animal—Animal into which a gene from another organism has been introduced by recombinant DNA methods. [Pg.161]

Numerous manufacturing systems are presently available for large-scale expression of recombinant proteins. Bacteria, yeast, mammalian cells, and transgenic animals have all been successfully utilized for large-scale production of recombinant biologies. In most cases the recombinant product is a cloned version of a previously purified human or animal protein thus reference standards are available for comparison. The FDA and the European Regulatory Agency have since developed standards for both the production... [Pg.39]


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See also in sourсe #XX -- [ Pg.55 , Pg.55 ]




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