Gene expression studies transgenic animals

For in vivo studies, animal models are set up and how the target is involved in the disease is analyzed. One such model is the use of knockout or transgenic mice (Exhibit 2.8). It should be borne in mind, however, that there are differences between humans and animals in terms of gene expression, functional characteristics, and biochemical reactions. Nevertheless, animal models are important for the evaluation of drug-target interactions in a living system. 

---