Transgenic animals constitutive promoters

Gene delivery constitutes an interesting approach to treat diseased striated muscles. Administration of pDNA coding for the dystrophin protein has been extensively studied in animal models of Duchenne or Becker muscular dystrophy and even evaluated in Phase 1 clinical trials. Although most of the cationic vehicles appeared to be relatively inefficient in promoting transgenic expression in the muscle tissue, D-SPM polycations were reported to show a transient increase in reporter gene expression after direct intramuscular injection in skeletal muscles with maximum efficiency. 

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