Biopharmaceuticals Derived from Transgenic Plants and Animals

Biopharmaceuticals Derived from Transgenic Plants and Animals 

Copyright (g) 2005 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim 

APHIS ture/Animal and Plants Health Inspection Service 

In parallel to these efforts to develop recombinant systems for the production of innovative drugs, the same recombinant DNA technology has been applied to im- 

The first successful therapeutic protein made in a transgenic system was human tissue plasminogen activator regulated by a milk-directed promoter for accumulation in mouse milk [5]. Human growth hormone, which was one of the first proteins produced using recombinant microbial systems in the early 1980s, became the first human protein expressed in plants (tobacco cells) in 1986 [6]. Since then, over 200 biotherapeutics of diverse origin. 

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Baez,). (2005) Biopharmaceuticals derived from transgenic plants and animals, in Modern Biopharniaceuticals, vol. 3 (ed. J. Knablein), Wiley-VCH Verlag GmbH, Weinheim, Germany, pp. 833-892. 

I 5 Biopharmaceuticals Derived from Transgenic Plants and Animals... 

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