Toxicity carcinogenicity

Toxicological Chronic toxicity Carcinogenicity Fertility study (multi-generation) Embryotoxicity (non-rodent) Acute/subacute toxicity in 2nd species Toxicokinetics... 

U.S. EPA may list a waste as hazardous for any and all of the above reasons. The majority of listed wastes fall into the toxic waste category. To decide if a waste should be a toxic listed waste, U.S. EPA first determines whether it typically contains harmful chemical constituents. An appendix to RCRA contains a list of chemical compounds or elements that scientific studies have shown to have toxic, carcinogenic, mutagenic, or teratogenic effects on humans or other life forms. If a waste contains chemical constituents found on the appendix list, U.S. EPA then evaluates 11 other factors to determine if the wastestream is likely to pose a threat in the absence of special restrictions on its handling. These additional considerations include a risk assessment and study of past cases of damage caused by the waste. 

The human and environmental protection goals in EUSES are human populations (workers, consumers, and man exposed via the environment) and ecological systems (micro-organisms in sewage treatment systems, aquatic ecosystems, terrestrial ecosystems, sediment ecosystems, and predators). Repeated dose toxicity, fertility toxicity, maternal toxicity, developmental toxicity, carcinogenic risk, and lifetime cancer risk can be calculated for the cases that literature data is available. 

Has the product or its components been assessed at any time for acute toxicity, carcinogenicity or irritant properties ... 

Bio/dynamics. 1980a. A twenty-four month oral toxicity/carcinogenicity study of acrylonitrile administered to Spartan rats in the drinking water. Biodynamics, Inc., Division of Biology and Safety Evaluation, East Millstone, NJ. Project No. BDN-77-28. 

Sulfonated azo dyes are widely used in different industries [16]. Some structure of sulfonated and unsulfonated azo dyes is shown in Fig. 1. These water-soluble azo dyes will enter the environment generally with wastewater discharge. Also, these sulfonated and unsulfonated azo dyes have a negative aesthetic effect on the wastewater, and some of these compounds and biodegraded products are also toxic, carcinogenic, and mutagenic [17]. There exists clear evidence that sulfonated azo dyes show decreased or no mutagenic effect compared to unsulfonated azo dyes... 

Caution Common organic extracting solvents are both volatile and flammable. Ignition can be caused by hot surfaces without the need of sparks or flames. Some solvents (particularly diethyl ether) can also form peroxides that are explosive when concentrated, especially when heating is involved. Some solvents may also be toxic, carcinogenic, and/or teratogenic. Always consult the Material Safety Data Sheets (MSDS) before using any solvent. 

Flammability or explosivity Corrosivity Toxicity Carcinogenicity or teratogenicity Breathability (noxious or poisonous fumes) Electrical (high voltage or current) Light (intense sources, such as lasers, UV lamps) Radioactivity/Radiation... 

In addition to antineoplastic, cytotoxic agents, there are cancer therapeutic or preventative drugs that are intended to be given on a chronic basis. This includes chemopreventatives, hormonal agents, immunomodulators, and so on. The toxicity assessment studies on these will more closely resemble those of more traditional pharmaceutical agents. Chronic toxicity, carcinogenicity, and Ml developmental toxicity (ICH A-B, C-D, E-F) assessments will be required. For a more complete review, the reader is referred to DeGeorge et al. (1998). 

Chronic toxicity, carcinogenicity Rats, mice 5% maximum dietary concentration for nonnutrients... 

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