Toxicant definition

Another problem Hes in the overlap of repeUent—toxicant definition, in that many toxicants are known to have repeUent effects (43). Pyrethrins are... 

Table 1. Results of a toxicity definition of some medicinal preparations on Colpoda steinii and TCF.

Thus, it is possible to make the conclusion, that the offered by us method can be used for the toxicity definition in a various objects. 

At the environmental objects toxicity definition with offered method will allow during short time to estimate the toxicity degree of of various objects after eco-disasters or acts of terrorism, with use of the toxic agents. Besides, suggested method does not demand a sterility and allows to use materials from the objects of the external environment, which are not sterile. 

Gillam PK. Methylene blue and serotonin toxicity definite causal link. Psychosomatics 2010 51 448-9. 

Lead structure According to Valler and Green s definition a lead structure is a representative of a compound series with sufficient potential (as measured by potency, selectivity, pharmacokinetics, physicochemical properties, absence of toxicity and novelty) to progress to a full drug development program [12]. 

Elemental boron and the borates are not considered to be toxic, and they do not require special care in handling. However, some of the more exotic boron hydrogen compounds are definitely toxic and do require care. 

Toxicology. The acute oral and dermal toxicity of naphthalene is low with LD q values for rats from 1780—2500 mg/kg orally (41) and greater than 2000 mg/kg dermally. The inhalation of naphthalene vapors may cause headache, nausea, confusion, and profuse perspiration, and if exposure is severe, vomiting, optic neuritis, and hematuria may occur (28). Chronic exposure studies conducted by the NTP ia mice for two years showed that naphthalene caused irritation to the nasal passages, but no other overt toxicity was noted. Rabbits that received 1—2 g/d of naphthalene either orally or hypodermically developed changes ia the lens of the eye after a few days, foUowed by definite opacity of the lens after several days (41). Rare cases of such corneal epithelium damage ia humans have been reported (28). Naphthalene can be irritating to the skin, and hypersensitivity does occur. 

I. GeUer, W. C. Stebbius, and M. J. Wayner, eds.. Test Methodsfor Definition of Effects of Toxic Substances on Behavior and Neuromotor Function, NeurobehavioralToxicology, Vol. 1, Suppl. 1, 1979. 

The mechanism of antibacterial activity is through inhibition of gram-positive bacterial cell-wall synthesis thus, the penicillins are most effective against actively multiplying organisms. Because mammalian cells do not have a definitive cell-wall stmcture as do bacteria, the mammalian toxicity of the penicillins is low. Allergic phenomena in patients following sensitization may occur. 

Some authorities question whether dmnkeimess can result from the inhalation of ethyl alcohol vapors. Experience has demonstrated that in any event such intoxication is indeed rare (281). There is no concrete evidence that the inhalation of ethyl alcohol vapor will cause cirrhosis. Liver function is definitely impaired during alcohol intoxication (282), making the subject more susceptible to the toxic effects of chlorinated hydrocarbons. 

Hazardous Wastes The U.S. EPA has defined hazardous waste in RCRA regulations, CFR Parts 260 and 261. A waste may be hazardous if it exhibits one or more of the following characteristics (1) ignitability, (2) corrosivity, (3) reactivity, and (4) toxicity. A detailed definition of these terms was first published in the Federal Register on May 19, 1980, pages 33, 121-122. A waste may be hazardous if listed in Appendix Wll. 

Control of metalloid content in natural objects, foodstuff and pharmaceuticals is an important task for modern analytical chemistry. Determination of elements such as Arsenic is necessary for evaluation of object toxicity, since their content in environment may exceed MCL (maximum contaminant level), posing hazard to human health. Elements such as Selenium in definite doses are healthy, but in greater quantities they produce toxic effect. 

A second problem concerns delimiting the mechanisms of action which should be included in the definition, to exclude effects which are a secondary consequence of overt toxicity in other body systems. For example, disruption to the endocrine system caused by general metabolic disturbance, such as in severe liver damage, should not be grounds for calling a chemical an ED. 

HAZARDOUS WASTE An Unofficial class of industrial wastes which have to be disposed of with particular care. In the UK the closest definition is for special wastes . Certain toxic organic wastes, such as PCBs, have to be burned in high-temperature incinerators. 

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