V series compounds

An extensive compilation of the properties of compound semiconductors may be found in the Landolt-Bn mstein reference books (13,14). Various subvolumes in the series cover the properties of elemental. III—V, II—V, and other less common semiconductors. Information may also be found concerning semiconductor technology. Another useful source of information is the EMIS data review series (15). These books describe the properties and technology of GaAs, HgCdTe, InP, AlGaAs, InGaAs, and the III—V nitride compounds. 

Cyclic hydroxamic acids and V-hydroxyimides are sufficiently acidic to be (9-methylated with diazomethane, although caution is necessary because complex secondary reactions may occur. N-Hydroxyisatin (105) reacted with diazomethane in acetone to give the products of ring expansion and further methylation (131, R = H or CH3). The benzalphthalimidine system (132) could not be methylated satisfactorily with diazomethane, but the V-methoxy compound was readil3 obtained by alkylation with methyl iodide and potassium carbonate in acetone. In the pyridine series, 1-benzyl-oxy and l-allyloxy-2-pyridones were formed by thermal isomeriza-tion of the corresponding 2-alkyloxypyridine V-oxides at 100°. 

VM also called Edemo is a "V-series" nerve agent closely related to the better-known VX nerve gas. Like most of the agents in the V-series (with the exception of VX), VM has not been studied extensively studied. Little known about this compound other than its chemical formula. Since it is structurally very similar to VX it can be assumed that most properties will be similar also. 

Kessler and Rieker (50) studied the barriers to rotation and equilibrium constants of a series of /V-(2,4,6-trialkylphenyl)acetamides (13). The barriers, which are generally low relative to those in the corresponding /V-methyl compounds, and equilibrium constants are summarized in Table 8. The barrier is large when... 

From this series, compound MCI-154 (CAS 98326-33-1) (30) has been investigated in detail [95,96]. In vivo studies (anaesthetized dogs) revealed that doses of 0.3-100 tg/kg (i.v. administration) of MCI-154 produce dose-dependent increases in dF/dtmax and cardiac output, and decreases in arterial blood pressure and total peripheral resistance. The positive inotropic effect of (30) has been found to be superior to that exhibited by amrinone and milrinone [97,98]. It has been stated that MCI-154 exerts its activity probably by increasing the calcium-ion sensitivity of the contractile protein system of the cardiac skinned fibres [99,100]. A recent investigation suggests that inhibition of phosphodiesterase III is an important component of its cardiotonic activity [101]. 

A series of heterocyclic /V-amidino compounds has been synthesised by Niigata et al., comprising triazoles,592 pyrazoles,593-595 and indazoles.596 All had inhibitory effects on the Maillard reaction, the IC50 values for the triazoles ranging from 6.6 to 30.0 jUM, with low toxicity. The compounds were considered to have potential applications in the treatment of diabetic complications and aging-related diseases, as well as in skin medication, cosmetics, food products, and beverages. 

These compounds were designated V-series agents for venomous. VX is an oily viscous liquid that is clear or amber colored, odorless, and tasteless. Symptoms of overexposure may occur within minutes or hours, depending upon the dose. Severe exposure symptoms progress to convulsions and respiratory failure. 

Ginsburg, V.A., and Yakubovich. A.Y., Synthesis of heteroorganic compounds of aliphatic series by the diazo method. Part 8. Synthesis of compounds of elements of group V. Organophosphorus compounds. Syntheses of bis- and /rii(haloalkyl)phosphines and some transformations of chloroalkyl derivatives of phosphorus, Zh. Ob.shch. Khim.. 28, 728. 1958 Chem. Abstr, 52, 17091g, 1958. 

In the series of /V-halo-1,2,3-triazoles, /V-chloro compounds 28 are the least stable more stable are /V-bromo- 33 and /V-iodo-1,2,4-triazoles 34 [55LA (593)207 70ZC220]. 

Hoffmann, D., J.D. Adams, K.D. Brunnemann, and S.S. Hecht Formation, occurrence and carcinogenicity of V-nitrosamines in tobacco products in V-Nitroso compounds, edited by R.A. Scanlan and S.R. Tannenbaum, Am. Chem. Soc. Symp. Series 174 (1981) 247-273. 

There are two kinds of nerve agents—the G-series consisting of tabun (GA), sarin (GB), soman (GD), and cyclosarin (GF) and the V-series VE, VG, VM and VX. GA was discovered in 1936 by the German scientist Gerhard Schrader. This was followed by GB in 1938, GD in 1944, and finally GF in 1949. VX was synthesized in early 1950s in Britain. The G-series agents are more volatile than the V-series nerve agents. At ambient temperatures, these compounds are volatile... 

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