Thioridazine

A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100 cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1-piperazinyl)-1 hloropropane (3.2 g) in solution in anhydrous xylene (20 cc) is added and the mixture heated under reflux for 5 hours. After treatment of the reaction products, a crude oily base (2.5 g) is obtained after treatment. By the addition of a solution of fumaric acid in ethanol to an ethanolic solution of the base, 3-dimethylsulfamoyl-10-(3-4 -methyl-1 -piperazinylpropyD-phenthiazine diacid fumarate (2.6 g) is obtained, melting point 182°C. The base recrystallized from ethyl acetate melts at about 140°C. [Pg.1469]

des Usines Chimiques Rhone-Poulenc British Patent 814,512 June 3, 1959 [Pg.1469]

Chemical Name 10-[2-(1-methyl-2-piperidyl)ethyl] -2-(methylthio)phenothiazine Common Name — [Pg.1469]

Trade Name Manufacturer Country Year Introduced [Pg.1469]

N-(m-methylmercapto-phenyl)-aniline (MP 59° to 61°C) is prepared by condensing m-methyl-mercapto-aniline (BP 163° to 165°C/16 mm Hg) with the potassium salt of o-chloro-benzoic acid and decarboxylating the resultant N-(m-methylmercapto-phenyl)-anthranilic acid (MP 139° to 141°C) by heating, and then distilling. [Pg.1470]

Ethanolpyridines are used mainly for vinylpyridine manufacture. However, 2-ethanolpyridine (22) is used to make the psychotropic agent thioridazine [50-52-2] (106), and the antispasmodic agent triquizium bromide [71731-58-3] (107). [Pg.340]

Alternately, the N-acylated derivative of the substituted phenothiazine (112) is oxidized to the corresponding sulfoxide by means of periodic acid. Saponification (113) followed by alkylation with the above side chain affords thioridazine (114)... [Pg.389]

When naltrexone is administered with thioridazine, the nurse monitors the patient for... [Pg.184]

Papadopoulos and Crammer5 5b studied the sulphoxide intermediates of thioridazine (152b) in man. [Pg.153]

F Melleril (Sandoz) 1 GB Melleril (Novartis) Mellerette (Novartis) Melleril (Novartis) J Melleril (Sandoz-Sankyo) USA Thioridazine HCl (Geneva)... [Pg.2025]

C7H5CIO2 118-91-2) see Amsacrine Diclofenac Flufenamic acid Thioridazine 4-chlorobenzoic acid... [Pg.2323]

C13H11NS2 7643-08-5) see Mesoridazine Thioridazine lV-(3-methylthiophenyl)anthranilic acid (CJ4H13NO2S 18902-93-7) see Thioridazine [4-(methylthio)phenyl]boronic acid (C7H,B02S 98546-51-1) see Rofecoxib 4-[4-(methylthio)phenyl]-2(5H)-furanone (CiiH, 02S 162012-28-4) see Rofecoxib... [Pg.2423]

Fig 1 Chromatogram of imipramine and phenothiazine derivatives after staining with Forrest reagent [4] 1 = imipramine, 2 = desipramine, 3 = clomipramine, 4 = lofepramine, 5 = trimipramine, 6 = thioridazine, 7 = chlorphenethazine, 8 = periciazine, 9 = promazine, 10 = promethazine. [Pg.184]

Blue, violet benperidole imiclopazine thiethylperazine thioridazine i... [Pg.185]

Blue, violet benperidole dihydroergotamine imiclopazine levomepromazine thiethylperazine thioridazine )... [Pg.426]

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