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Thioridazine cardiovascular effects

Cardiovascular effects. Postural hypotension may result from blockade of a-adrenoceptors it is dose-related. Prolongation of the QT interval in the cardiac cycle may rarely lead to ventricular arrhythmias and sudden death (but particular warnings and constraints apply to the use of thioridazine and pimozide). [Pg.386]

Clinically relevant interactions were not noted when moclobemide was given with one or more neuroleptics (including phenothiazines such as chlorpromazine, levomepromazine, thioridazine). Adverse effects such as hypotension, tachycardia, drowsiness, tremor, and constipation were somewhat more Sequent, probably due to additive effects. A fatal case of overdose with moclobemide and perazine was attributed to syn-ergisSc effects resulSng in funcSonal cardiovascular disorder. ... [Pg.1141]

Cardiovascular side effects. Ziprasidone produced a mean QTc prolongation of 21 ms at maximal blood levels achieved with typical therapeutic doses. However, in all clinical trials, the rate of QTc intervals greater than 500 ms (considered a threshold for arrhythmia risk) did not differ from the rate associated with placebo (<0.1%). The QTc effect of ziprasidone is larger than that of other atypical antipsychotics but smaller than that of thioridazine. Blood levels of ziprasidone increased about 40% when ketoconazole (a metabolic inhibitor) was coadministered, and no change in QTc duration was detected. [Pg.122]

Hypotension is the most commonly observed cardiovascular adverse effect of neuroleptic drugs, particularly after administration of those that are also potent alpha-adrenoceptor antagonists, such as chlorpromazine, thioridazine, and clozapine (34). A central mechanism involving the vasomotor regulatory center may also contribute to the lowering of blood pressure. [Pg.263]

Pinoxepin (25) was compared with thioridazine in a cooperative double-blind study. The drugs were equipotent. The former produced more extrapyramidal symptoms while the latter displayed more notable cardiovascular side effects. ... [Pg.4]


See other pages where Thioridazine cardiovascular effects is mentioned: [Pg.332]    [Pg.63]    [Pg.608]    [Pg.609]   
See also in sourсe #XX -- [ Pg.305 ]




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