Flufenamic acid

The aluminum salts of dmgs are significant for two principal reasons reduction of dmg acidity in the stomach lining and reduction of undeskable flavor. Examples are the aluminum salts of glycine, acetylsahcyhc acid, ibuprofen, flurbiprofen, fenoprofen, flufenamic acid, oxaprozin, and a variety of aminobenzoic acid. Some of these compounds are Hsted in Table 2. 

Aluminum flufenamate, tris-[2-(3-trifluoromethylphenyl)aminoben2oate]aluminum, is a safer and more effective analgesic than aspirin (94). The dihydroxyalurninum flufenamate is made by reaction of flufenamic acid with aqueous caustic, followed by addition of aluminum chloride with stirring at 42°C for 15 min to give 99% yield (95). Both forms are less irritating and less toxic than the parent acid or aspirin (94,95). 

Flufenamic acid (162) is a reasonably well-established NSAID (Non Steroidal Anti Inflammatory Drug). Alkylation of its potassiuni salt with the hydroxyethyl ethyl ether of ethylenechlo-rohydrin affords the latendated derivative etofenamate (163) [41]. Antiinflammatory activity is apparently retained when both rings in the fenamate series carry carboxyl groups. Thus, condensation of dichlorobenzoic acid 164 with anthranilic acid (165) by means of nucleophilic aromatic... 

A new class of compounds able to form lamellar structures consisting of bilayers separated by water-layers are dialkylammonium-salts of 2-[((trifluormethyl)-phenyl)-amino]-benzoic acid (Flufenamic acid) as was found by Eckert and Fischer 80). 

C7H5CIO2 118-91-2) see Amsacrine Diclofenac Flufenamic acid Thioridazine 4-chlorobenzoic acid... 

C24H33FOfi 1524-88-5) see Flunisolide flufenamic acid potassium salt (C14H9F3KNO2 35982-11-7) see Etofenamate flumetasone acetate... 

C7HjFjN 98-16-8) see Bendroflumethiazide Flufenamic acid Flutamide Hydroflumethiazide Niflumic acid... 

Anthranilic acid derivatives, such as flufenamic acid (35), constitute another effective series of non-steroidal antiinflammatory agents. Homologation... 

Substantial interest in the pharmacological properties of the nonsteroidal antiinflammatory agents related to mefenamic and flufenamic acid led to examination of a series of aminopyridines instead... 

A number of compounds activate TRPA1 without any apparent ability to form covalent adducts, including nonelectrophilic fenamate nonsteroidal anti-inflammatory drugs (NSAIDs), such as flufenamic acid (17, FFA), niflumic acid (18, NFA), and mefenamic acid (19, MFA) [13]. Phenols such as thymol (20) and 2-ferf-butyl-5-methylphenol (21) have been shown to activate human TRPA1 with micromolar EC50 values in stably transfected HEK293 cells [14]. 

Diclofenac Diflunisal Fenoprofen Flufenamic acid Flurbiprofen... 

White MM, Aylwin M. 1990. Niflumic and flufenamic acids are potent reversible blockers of Ca -activated Cl channels in Xenopus oocytes. Mol Pharmcol 37 720. 

Y. Hu, J.K. Liang, A.S. Myerson and L.S. Taylor, Crystallization monitoring by Raman spectroscopy Simultaneous measurement of desupersaturation profile and polymorphic form in flufenamic acid systems, Ind. Eng. Chem. Res., 44, 1233-1240 (2005). 

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