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Thioridazine adverse effects

Clinically relevant interactions were not noted when moclobemide was given with one or more neuroleptics (including phenothiazines such as chlorpromazine, levomepromazine, thioridazine). Adverse effects such as hypotension, tachycardia, drowsiness, tremor, and constipation were somewhat more Sequent, probably due to additive effects. A fatal case of overdose with moclobemide and perazine was attributed to syn-ergisSc effects resulSng in funcSonal cardiovascular disorder. ... [Pg.1141]

Thioridazine (Mellaril) Greater potential for CNS and extrapyramidal adverse effects. High... [Pg.1393]

The term behavioral toxicity has been used in the child psychiatry literature to describe the following adverse effects of antipsychotics, particularly low-potency phenothiazines (e.g., chlorpromazine, thioridazine) ... [Pg.282]

Much is also made of the observation that the newer atypical neuroleptics impact on a greater variety of neurotransmitter systems than the older ones (e.g., Lieberman et al., 2005b). However, there is no reason to suspect that impacting on multiple neurotransmitter systems would improve either safety or efficacy. To the contrary, it would seem bound to increase the spectrum of adverse effects. But even in regard to their impact on multiple neurotransmitter systems, the atypicals are not unique. All of the older neuroleptics affect at least three neurotransmitter systems, such as serotonin and histamine, and several affect four or five of them. For example, old-fashioned thioridazine (Mellaril) impacts at least five neurotransmitter systems. [Pg.24]

Hypotension is the most commonly observed cardiovascular adverse effect of neuroleptic drugs, particularly after administration of those that are also potent alpha-adrenoceptor antagonists, such as chlorpromazine, thioridazine, and clozapine (34). A central mechanism involving the vasomotor regulatory center may also contribute to the lowering of blood pressure. [Pg.263]

The authors thought that the pigmentary changes were probably due to thioridazine, as adverse effects on the retina are rare with chlorpromazine. [Pg.364]

Other consequences of banning thioridazine have been reported in a rural general practice in Ireland, in which 29 of 40 GPs responded to a questionnaire and 17 reported management problems and adverse reactions (29). There was increased service demand, as 44% of the GPs described up to a 50% increase in referrals to the mental health service although most of the GPs (67%) reported satisfaction with alternative agents, 37% described adverse effects associated with the alternative agents. It seems reasonable that directives should incorporate the flexibility required to accommodate the needs of patients who are already successfully stabilized on these drugs. [Pg.365]

ANTIPSYCHOTICS-CHLORPROMAZINE, CLOZAPINE, HALOPERI-DOL, OLANZAPINE, PERPHENAZINE, RISPERIDONE, SERTINDOLE, THIORIDAZINE, ZUCLOPENTHIXOL H2 RECEPTOR BLOCKERS -CIMETIDINE t plasma concentrations of these antipsychotics, with risk of associated adverse effects Cimetidine is an inhibitor of CYP3A4 (sertindole, haloperidol, risperidone), CYP2D6 (chlorpromazine, risperidone, zudopenthixol, thioridazine, perphenazine) and CYP1A2 (clozapine, olanzapine, sertindole, haloperidol) Avoid concomitant use. Choose an alternative acid suppression, e.g. H2 antagonist... [Pg.262]

In some classifications thioridazine and sulpiride are considered to be atypical due to their low propensity to cause extrapyramidal adverse effects. [Pg.381]

Procyclidine may reduce the antipsychotic effectiveness of haloperidol and phenothiazines, possibly by direct CNS antagonism related to its anticholinergic properties. Haloperidol and phenothiazine exert their effects in part by blocking the hyperactivity of dopaminergic transmission in the mesocortical and mesolimbic systems. Concomitant use with phenothiazine derivatives, especially thioridazine having pronounced anticholinergic effects, also increases the risk of anticholinergic adverse effects. Paralytic ileus may result from concomitant use with phenothiazines or tricyclic antidepressants. Concomitant use with alcohol and other CNS depressants increases procyclidine s sedative effects. [Pg.592]

The typical antipsychotic drugs (e.g., chlorpromazine, thioridazine, fluphenazine, and haloperidol) act primarily as DA antagonists, blocking Dj receptors. Side effects include the induction of pseudo-Parkinsonism, akathisia, and/or acute dystonic effects. Their use and symptom management are discussed, as are other adverse effects including toxicity, tardive dyskinesia, and neuroleptic malignant syndrome. [Pg.160]

Parkinsonian adverse effects occur more commonly with haloperidol than with thioridazine. One possible explanation is that thioridazine exerts more pronounced blocking actions at brain muscarinic receptors. This action partly compensates for dopamine receptor blockade in the ni-grostriatal tract, so that extrapyramidal function is more effectively maintained. A second possibility (not listed) is that haloperidol has a higher affinity for dopamine D2 receptors than does thioridazine. The answer is (D). [Pg.267]

The detrimental effects of alcohol on the skills related to driving are made worse by chlorpromazine, and, to a lesser extent, by flu-pentixol, sulpiride and thioridazine. Small or single-dose studies with haloperidol or tiapride surest that any interaction would seem to be mild nevertheless, all antipsychotic drugs which cause drowsiness have the potential to enhance the effects of alcohol. There is evidence that drinking can precipitate the emergence of extrapyramidal adverse effects in patients taking antipsychotics. [Pg.50]

On the whole no significant adverse interactions appear to occur between the antipsychotics and the SSRIs. However, a number of case reports describe extrapyramidal adverse effects following the use of fluoxetine or paroxetine with an antipsychotic, and ga-lactorrhoea and amenorrhoea developed in one patient given loxapine and fluvoxamine. Fluoxetine and fluvoxamine appear to raise haloperidol levels, which may increase adverse effects. Thioridazine levels are expected to be increased with fluoxetine, fluvoxamine, or paroxetine treatment with a risk of QT interval prolongation. [Pg.712]

A study in 10 schizophrenic patients found that when fluvoxamine 50 mg daily was added to established treatment with thioridazine 30 to 200 mg daily, thioridazine plasma levels were increased by 225%. There were no reported changes in either clinical status or adverse effects. ... [Pg.713]


See other pages where Thioridazine adverse effects is mentioned: [Pg.161]    [Pg.113]    [Pg.287]    [Pg.321]    [Pg.218]    [Pg.152]    [Pg.107]    [Pg.230]    [Pg.63]    [Pg.195]    [Pg.282]    [Pg.294]    [Pg.270]    [Pg.321]    [Pg.259]    [Pg.187]    [Pg.216]    [Pg.363]    [Pg.416]    [Pg.2438]    [Pg.2469]    [Pg.3397]    [Pg.124]    [Pg.152]    [Pg.1270]    [Pg.61]    [Pg.109]    [Pg.588]   
See also in sourсe #XX -- [ Pg.559 ]

See also in sourсe #XX -- [ Pg.756 ]

See also in sourсe #XX -- [ Pg.1221 , Pg.1222 , Pg.1270 ]

See also in sourсe #XX -- [ Pg.308 , Pg.591 , Pg.1111 ]




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