Sexuality thioridazine

The piperidines, e.g. thioridazine, pipothiazine and pericyazine, have the lowest potential to cause extrapyramidal effects. Thioridazine is one of the most sedative phenothiazines. It may decrease the inotropic activity of digitalis by its quinidine-like action, which can cause myocardial depression, decreased efficiency of repolarization, and increased risk of tachyarrhythmias. With thioridazine drug induced sexual dysfunction and especially cardiotox-icity with prolongation of the QT-interval are more frequently seen than with other phenothiazines. For the above reasons thioridazine is withdrawn from the market in many countries. 

Thioridazine and other highly anticholinergic drugs can cause male sexual dysfunction, including impotence and retrograde ejaculation 24,25. A case of thioridazine-... 

Thioridazine retinal pigmentation at high doses, sexual dysfunction. 

A detailed study of the effects of thioridazine on sexual function in males has been reported. 

Some degree of sexual dysfunction was reported by 60% of patients on thioridazine compared with 25% on other major tranquillizers. The changes in ejaculation seemed to be specifically related to the taking of thioridazine (48 ). 

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