Interpretation of the Results

The measurement of filth elements by microanalysis is a valuable adjunct in the enforcement of the Food, Drug, and Cosmetic Act and serves as an efficient means of evaluating conditions of cleanliness, decency, and sanitation in food-producing plants. This, of course, is in addition to the value of microanalytical methods in the determination of the fitness of foods as they reach the consumer. The techniques available, together with proficiency of manipulation, repeated references to authentic materials, and sound judgment in the interpretation of results, provide effective enforcement weapons in the constant war to prevent the production and interstate distribution of products which are unfit for the table of the American consumer. 

The pursuit of operations research consists of (a) the judgment phase (what are the problems ), (b) the research phase (how to solve these problems), and (c) the decision phase (how to act on the finding and eliminate the problems). These phases require the evaluation of objectives, analysis of an operation and the collection of evidence and resources to be committed to the study, the (mathematical) formulation of problems, the construction of theoretical models and selection of measures of effectiveness to test the models in practice, the making and testing of hypotheses as to how well a model represents the problem, prediction, refinement of the model, and the interpretation of results (usually as possible alternatives) with their respective values (payoff). The decision-maker generally combines the findings of the... 

As pointed out above, accumulatory pressure and weight loss measurements usually refer to the total reaction. When there are several volatile products, it is necessary to identify all components and investigate progressive changes in gas composition. Quantitative determinations of the amounts of each product (EGA) should, ideally, be combined with measurements of the total extent of reaction, although Gam [143] has recommended caution in the interpretation of results from simultaneous measurements. 

The variations of dielectric constant and of the tangent of the dielectric-loss angle with time provide information on the mobility and concentration of charge carriers, the dissociation of defect clusters, the occurrence of phase transitions and the formation of solid solutions. Techniques and the interpretation of results for sodium azide are described by Ellis and Hall [372]. 

Research use of analytical results in the framework of a nonanalytical setting, such as a governmental investigation into the spread of pollution here, a strict protocol might exist for the collection of samples (number, locations, time, etc.) and the interpretation of results, as provided by various consultants (biologists, regulators, lawyers, statisticians, etc.) the analytical laboratory would only play the role of a black box that transforms chemistry into numbers in the perspective of the laboratory worker, calibration, validation, quality control, and interpolation are the foremost problems. Once the reliability and plausibility of the numbers is established, the statisticians take over. 

Many investigators have studied the in vivo degradation kinetics of lactide/glycolide materials (5,35-39). There has been some confusion in the interpretation of results primarily because of lack of consistency in nomenclature and careful attention in describing the specific stereoisomers evaluated. Nevertheless, the overall degradation kinetics are fairly well established for the entire family of homopolymers and copolymers. At the present, this common knowledge of the in vivo lifetimes of various lactide/glycolide polymers is a primary reason for their popularity. 

In principle, these approaches are very attractive because they probe multiple pathways in the critical regions where the pathways are separated, but in practice these are extremely challenging experiments to conduct, and the interpretation of results is often quite difficult. Furthermore, these experiments are difficult to apply to bimolecular collisions because of the difficulty of initiating the reaction with sufficient time resolution and control over initial conditions. 

The carryover effect is only one type of issue that may complicate the interpretation of results from a cross-over study. A more complete description of the potential pitfalls in the analysis of cross-over studies is beyond the scope of this chapter. The reader should simply be aware that, although cross-over studies may be less expensive to conduct than parallel trials initially, they also carry a higher risk of producing results that are fficult or impossible to interpret, thus requiring that the study be repeated to obtain clear results. 

Interpretation of test results. The outcomes of tests are compared with norms and tolerances to determine sizes and directions of deviations. It is important to discuss how operators and QA managers who judge test results should be informed about the interpretation of results and which decision-support systems such as control charts are relevant. 

However, care must be exercised in the interpretation of results that show the presence of putative metabolites. An illustrative example is provided by a study of the biodegradation... 

It can be seen that these definitions are derived from experimental observation and are no more than classifications based on a set of properties shared by a group of substances. They are scientifically inadequate for the interpretation of results, which requires a definition based on concepts. Historically, the attempt to provide a model rather than a classification comes in the form of a search for imderlying universal principles. It seems that the alchemists recognized vague principles of acidity and alkalinity, and in the 17th century the iatrochemists made these the basis of chemical medicine. Disease was attributed to a predominance of one or other of these principles (Pattison Muir, 1883). 

As discussed above, it is important to try to optimize biological, physicochemical, and ADME properties in parallel. However, the data from all of these assays for the numerous compounds prepared by parallel synthesis make the interpretation of results challenging. The use of tools such as MVA helps in the effective utilization of all data in the optimization process. 

The use of excess inert electrolyte so as to reduce differences in transport properties of the solution at the electrode surface and in the bulk. In such a solution, the ionic diffusivity of the reacting ion, for example, Cu2 + or Fe(CN)g, should be employed in the interpretation of results, and not the molecular diffusivities of the compounds, for example, CuS04 or K3Fe(CN)6. 

A much explored pathway to simple silenes involves the thermolysis of silacyclobutanes at 400-700°C, the original Gusel nikov-Flowers (155) route. Such temperatures are not readily conducive to the isolation and study of reactive species such as silenes except under special conditions, and flash thermolysis, or low pressure thermolysis, coupled with use of liquid nitrogen or argon traps has frequently been employed if study of the physical properties is desired. Under these high temperature conditions rearrangements of simple silenes to the isomeric silylenes have been observed which can lead to complications in the interpretation of results (53,65). Occasionally phenyl-substituted silacyclobutanes have been photolyzed at 254 nm to yield silenes (113) as has dimethylsilacyclobutane in the vapor phase (147 nm) (162). 

Another noteworthy example is x-ray absorption fine structure (EXAFS). EXAFS data contain information on such parameters as coordination number, bond distances, and mean-square displacements for atoms that comprise the first few coordination spheres surrounding an absorbing element of interest. This information is extracted from the EXAFS oscillations, previously isolated from the background and atomic portion of the absorption, using nonlinear least-square fit procedures. It is important in such analyses to compare metrical parameters obtained from experiments on model or reference compounds to those for samples of unknown structure, in order to avoid ambiguity in the interpretation of results and to establish error limits. 

EC, Commission Decision of 12 August 2002 implementing Council Directive 96/ 23/EC concerning the performance of analytical methods and the interpretation of results... 

In Chapter 1 a general pattern for analytical procedures was introduced and the various stages of an analysis identified as sampling pretreatment separation or masking measurement interpretation of results. Subsequent chapters have dealt with separation methods, measurement techniques and the interpretation of results in more detail. It remains to examine sampling more closely and to consider, by way of example, some overall analytical schemes. 

Pharmaceuticals, unlike industrial chemicals, agricultural chemicals, and environmental agents, are intended to have human exposure and biological activity. And, unlike these materials and food additives, pharmaceuticals are intended to have biological effects on the people that receive them. Frequently, the interpretation of results and the formulation of decisions about the continued development and... 

The development of medium and high density polyethylene pressure pipes over the last thirty years has led to an extensive database on their stress-rupture behaviour, with associated standards for their testing and the interpretation of results [1, 2], Various forms of PVC are also used. The accelerated testing of gas and water pipes is introduced as an example of a field where there is a large database of pressure testing on which current regulations are based, the number of polymers is limited and accelerated tests are widely used (unusually, with two accelerating parameters). 

Information on the kinetics of complex ion reactions in high acid is sparse, partly because of the instability problems, but also because of the difficulties in the interpretation of results in such a complex medium. 

In addition to the complementary role of these techniques in collecting experimental information, strong and useful interplay is possible in the interpretation of results obtained by these methods. The interrelationship of electron diffraction with mass spectrometry and vibrational spectroscopy is sketched in Fig. 2. This scheme was compiled from the viewpoint of the electron diffraction analysis. Some examples of appUcation will be discussed below. 

Surface chemical characterization of the passivation layer on the Al surface has been performed mainly via XPS, and the interpretation of results generated by various researchers still remains controversial. Because salt anions with active fluorine (LiPFe, LiAsFe, and LiBF4) are able to form stable surface layers on Al and protect it from corrosion, early studies had suggested that fluoride species such as LiF and AIF3 are crucial to the protection. 

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