Tert Hydrochlorid

B-IN-benzyl-N-tert-butylglycvDsalicvlic acid methyl ester hydrochloride... 

Common Name a-benzylisopropylamine hydrochloride phenyl-tert-butylamine hydrochloride... 

Step B A solution of the 3-tert-butylamino-2-oxopropanol in a mixture of pyridine hydrochloride and pyridine is treated with p-toluenesulfonylchloride. The mixture is stirred for /i hour at 25° to 30°C and then poured into cold water. The solution is treated with potassium carbonate and the pyridine evaporated in vacuo at a temperature between 55° and 60°C. The aqueous residue is treated with potassium carbonate and the mixture extracted with methylene chloride. Evaporation of the dried extract provides 1-toluene-sulfonyloxy-2-oxo-3-tert-butylaminopropane. 

Step D Chemical Reduction Preparation of 3-Morpholino-4-(3-tert-Butylamino-2-Hydroxy-propoxyl-l,2,5-Thiadiazole — The 3-morpholino-4-(3-tert-butylamino-2-oxopropoxy)-1,2,5-thiadiazole (0.01 mol) is dissolved in isopropanol (10 ml). To the solution is added sodium borohydride in portions until the initial evolution of heat and gas subsides. The excess sodium borohydride is destroyed by addition of concentrated hydrochloric acid until the mixture remains acidic. The precipitate of sodium chloride is removed, ether is added, and the solution is concentrated to crystallization. The solid material is removed by filtration and dried thus providing 3-morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole, MP 161° to 163°C (as hydrochloride). 

Benoxinate hydrochloride Bumetanide Fluocortin butyl Pentobarbitol sodium p-n-Butoxy acetophenone Dyclonine HCI Butoxybenzyl bromide Butropium bromide 7-[D-0 -tert-Butoxycarbonylamino-a -... 

Penicilloic acid 5, the substrate for the projected lactamization reaction, could be derived from the suitably protected intermediate 6. Retrosynthetic disassembly of 6, in the manner illustrated, provides D-penicillamine hydrochloride (7) and tert-butyl phthalimido-malonaldehydate (8) as potential building blocks. In the synthetic direction, it is conceivable that the thiol and amino groupings in 7 could be induced to converge upon the electrophilic aldehyde carbonyl in 8 to give thiazolidine 6 after loss of a molecule of water. 

CisHisLNjO 154371-62-7) see Eprosartan tert-butyl 4,4 -dimethoxy-a-stilbenyl sulfide (C20H24O2S) see Raloxifene hydrochloride tert-butyl 4,4 -dimethoxy-a-stilbenyl sulfoxide (C20H24O3S 186408-54-8) see Raloxifene hydrochloride l-butyl-2-(2,6-dimethylanilinocarbonyl)pyridinium bromide... 

Trichloromethyl chloroformate has proven effective in the preparation of N-carboxy-a-amino acid anhydrides from amino acids, and various compounds having isocyanate, acid chloride, and chloroformate groups.For example, trichloromethyl chloroformate may be used instead of phosgene in the preparation of 2-tert-butoxycarbonyloxyimino-2-phenylacetonitrile. The use of this reagent is illustrated here by the synthesis of 3-isocyanato-propanoyl chloride from 3-aminopropanoic acid hydrochloride. 

Treatment of the sulfoxide 1222 a with tert-butyldimethylsilyl chloride 85 a and excess imidazole in DMF at 25 °C furnishes the imidazole derivative 1223a in 70% yield, whereas the phenyl derivative 1222b affords, besides 47% of 1223b , the cyclized product 1224 in 24% yield and 94 a and imidazole hydrochloride [34] (Scheme 8.14). Reaction of 1225 with N-(trimethylsilyl)imidazole 1219 at 170°C affords 1226 in 50% yield [35]. 

Boc-Glyctne tert-butyl ester can be prepared by treatment of glycine teit-butyl ester hydrochloride (Aldrich Chemical Company, Inc.) with di-tert-butyl dicarbonate (Fluka Chemical Corporation) and triethylamine in THF.2... 

Glycine tert-butyl ester hydrochloride Glydne, tert-butyl ester, hydrochloride (8) Glycine, 1,1-dimethylethyl ester, hydrochloride (9) (27532-96-3)... 

C. 4-Ketop/pecolic acid hydrochloride. tert-Butyl [1-(tert-butoxycarbonyl)-3-oxo-4-pentenyl]carbamate, 8.73 g (0.0308 mol), is dissolved in 280 mL of an ice-cooled, saturated solution of hydrogen chloride in ether. The solution is kept without stirring at room temperature overnight. The resulting suspension is filtered and the... 

N-tert-Butoxycarbonyl-L-serinal from D-Glucosamine Hydrochloride. T. Henk, T. Kolter, and A. Giannis, Institut fOr Organische Chemie und Biochemie der Universitat Bonn, Gerhaid-Domagk-Str. 1,... 

Example (+) Amphetamine Sulphate-a pri-amine salt, -Ephedrine Sulphate-a sec-amine salt, and Quinine Hydrochloride-a tert-amine salt. 

Dinitrocubane (28) has been synthesized by Eaton and co-workers via two routes both starting from cubane-l,4-dicarboxylic acid (25). The first of these routes uses diphenylphos-phoryl azide in the presence of a base and tert-butyl alcohol to effect direct conversion of the carboxylic acid (25) to the tert-butylcarbamate (26). Hydrolysis of (26) with mineral acid, followed by direct oxidation of the diamine (27) with m-CPBA, yields 1,4-diiutrocubane (28). Initial attempts to convert cubane-l,4-dicarboxylic acid (25) to 1,4-diaminocubane (27) via a Curtins rearrangement of the corresponding diacylazide (29) were abandoned due to the extremely explosive nature of the latter. However, subsequent experiments showed that treatment of the acid chloride of cubane-l,4-dicarboxylic acid with trimethylsilyl azide allows the formation of the diisocyanate (30) without prior isolation of the dangerous diacylazide (29) from solution. Oxidation of the diisocyanate (30) to 1,4-dinitrocubane (28) was achieved with dimethyldioxirane in wet acetone. Dimethyldioxirane is also reported to oxidize both the diamine (27) and its hydrochloride salt to 1,4-dinitrocubane (28) in excellent yield. ... 

Methyl acetimidate hydrochloride, methyl glycinate hydrochloride, potassium tert-butoxide, and methyl formate were purchased from Aldrich Chemical Company, Inc., and were used without further purification. The checkers purchased methyl glycinate hydrochloride from Tokyo Chemical Industry Co. and potassium tert-butoxide and methyl formate from Kanto Chemical Co. Step A is very sensitive to moisture. Ethyl acetimidate hydrochloride is very hygroscopic. It must be dried before use in a desiccator over phosphorus pentoxide (P2O5) under reduced pressure and handled under argon. 

Scheme 6.44 Reaction sequence for the synthesis of enantiopure (/ )-tert-leucine hydrochloride starting from the pivalaldimine Strecker adduct obtained under catalysis with polymer-bound thiourea 41.

In ahnlicher Weise erhalt man z.B. die Hydrochloride von 4-Chlor-anilin (70%), 4-Meth-oxy-anilin (55%) und 2-tert.-Butyl-anilin (42%, bei umgekehrter Zugabe der Grignard-Verbindung zum Azid). 

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