Butropium bromide

Chemical Name (3(S)-endol -8-[(4-butoxvphenvl)methyl] 3-(3-hydroxy-1-oxo-2-phenyl-propoxy)-8-methyl-8 azoniabicyclo[3.2.1] octane bromide 

To 1(K) ml of an isopropanol solution containing 11.8 grams of hyoscyamine base were added drop by drop with stirring 10 ml of an isopropanol solution containing 11 grams of p-n-butoxybenzyl bromide. After a while, the reaction mixture had a turbid appearance followed by separation of white crystals. 

After stirring for 5 hours at room temperature, the crystals were recovered by filtration, which were then recrystallized from 120 ml of isopropanol. There was obtained 15.8 grams of white needles having the melting point of 158°-160°C. 

Tanaka, S. and Hasimoto, K. U.S. Patent 3,696,110 October 3,1972 assigned to Eisai, KK, Japan 

Chemical Name 3,7-Dlhydro-8-[(2+iydroxyethyl)methylamino]-1,3,7-trimethyl-1 H-purine-2,6-dlone 

Chemical Name 3,7 Dihydro-8-[(2-hydroxyethyl)methylamino] -1,3,7-trimethyl-l H-purlne- 

Merck Index 1507 Kleeman Engel p. 131 OCDS Vol. 2 P.308 (19B0) 

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Benoxinate hydrochloride Bumetanide Fluocortin butyl Pentobarbitol sodium p-n-Butoxy acetophenone Dyclonine HCI Butoxybenzyl bromide Butropium bromide 7-[D-0 -tert-Butoxycarbonylamino-a -... 

Bucainide, 125 Bucloxic acid, 126 Buformin, 21 Bufuralol, 110 Burnetanide, 87 Bunaftine, 211 Bunamidine, 212 Bunitridine, 215 Bunitrolol, 106, 110 Bunolol, 110, 215 Bupicomide, 280 Buprenorphine, 321 Bupropion, 124 Burimamide, 251 Buspirone, 300 Butacetin, 95 Butamirate, 76 Butaclamol, 226 Butorphanol, 325 Butropium bromide, 308... 

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