Methyl glycinate

Maps and Conformational Transitions Between Low-Energy Conformers of N-Acety 1-N -Methyl Glycine Amide An Ab Initio Study at the 4-21G Lever with Gradient Relaxed Geometries. J. Mol. Struct. (Theochem) 124, 143-153. 

Fig. 7.19 Illustration of the additivity of conformational geometry functions for the -ro-tation in (CH3CO)(H)N-C(CH3)(H)(CONHCH3) (ALA). During the torsional motion about the N-C(a) bond of ALA, the interactions within the system are the same as those encountered during the N-C torsion in N-ethyl acetamide (NEA), plus those encountered during the N-C(a) torsion in N-acetyl N -methyl glycine amide offset by 120° as shown (GLY), minus those encountered during the N-C torsion in N-methyl acetamide (NMA).

Add to the fullerene solution with mixing, 25 mg of N-methyl glycine (sarcosine) and 20 mg of paraformaldehyde. 

Cyclopentane-carboxylic acid Methyl glycinate TBTU Peptides 98 2005HGA1711... 

Arenoxyacetic acid Methyl glycinate DCC Heteroditopic receptors 71 2006CJC58... 

N-alkyl N-benzyl N-methyl glycines, C H2n+fi (CH2C6H5)(CH3)CH2C00 . 

EPPS, also called HEPPS) N-Tris(hydroxymethyl)methyl-glycine (Tricine) N,N-Bis(2-hydroxyethyl)glycine (Bicine)... 

A. Methyl a-[(methoxyethylidene)amino]acetate (1). A flame-dried, 500-mL, twonecked, round-bottomed flask is equipped with a stir bar, rubber septum, eind an argon inlet. The flask is charged with methyl acetimidate hydrochloride (10.0 g, 91 mmol) (Note 1) and dry dichloromethane (140 mL) (Note 2). The stirred suspension is cooled to 0°C and solid methyl glycinate hydrochloride (11.5 g, 91 mmol, Note 1) is added in one portion with a powder funnel under a stream of Ar. After the mixture is stirred for 45 min at 0°C, a solution of dry triethylamine (12.7 mL, 91 mmol) (Note 2) in dry dichloromethane (11 mL) is added via syringe pump during 2.5 hr. Stirring is continued for 5 hr while the mixture is... 

Methyl acetimidate hydrochloride, methyl glycinate hydrochloride, potassium tert-butoxide, and methyl formate were purchased from Aldrich Chemical Company, Inc., and were used without further purification. The checkers purchased methyl glycinate hydrochloride from Tokyo Chemical Industry Co. and potassium tert-butoxide and methyl formate from Kanto Chemical Co. Step A is very sensitive to moisture. Ethyl acetimidate hydrochloride is very hygroscopic. It must be dried before use in a desiccator over phosphorus pentoxide (P2O5) under reduced pressure and handled under argon. 

Methyl glycinate hydrochloride ALDRICH Glycine methyl ester hydrochloride Glycine, methyl ester, hydrochloride (8,9) (5680-79-5)... 

The best alkylation occurs at low temperature in the presence of 10 12 equivalents of hexamethylphosphoric triamide (HMPA). Without IIMPA, the enantiomeric excesses arc lower and the methylation is slower. Furthermore, the chiral moiety of the mixed sulfate, as well as the Schiff base moiety of the methyl glycinate, determines the outcome of the a-alkylations. 

Lithium enolates of various Schiff bases of methyl glycinate have been alkylated using the standard conditions (Table 2). 

Fatty Acid—Sarcosine Condensates. These surfactants are prepared by the reaction of fatty acid chlorides with methyl glycine sodium lauroyl sarcosinate [137-16-6] is an example of this group. They are most effective at pH 5.5—6.0 for foaming activity in soft to moderately hard water. The action of these deteigents is gready reduced under severe hard water conditions. The sarcosinates exhibit compatibility with cationic surfactants and have been suggested for use in formulation of conditioning shampoos (7). 

Table 4 Rate Constants for the Metal Ion-promoted Hydrolysis of Methyl Glycinate and Ethyl Glycinate...

Table 6 Activation Parameters for the Hydrolysis of Methyl Glycinate in the Presence of Metal Nitriloacetates and Tetradentate Nickel(ll) Chelates at 1 = 0.1 M ...

Table 7 Rate Constants (kOH) and Equilibrium Constants (log KCuL) Associated with the CuL-promoted Hydrolysis of Methyl Glycinate at 25 °C...

Table 3-1. Rate constants for the hydrolysis of methyl glycinate, H2NCH2C02Me, in neutral water, in dilute acid and in the presence of copper(n) salts.

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