4- -imidazole.hydrochloride

Chemical Name 1-(1-Phenylethyl)-5-(ethoxy-carbonyl)imidazole hydrochloride Common Name —... 

Chemical Name 4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1 H-imidazole hydrochloride... 

Treatment of the sulfoxide 1222 a with tert-butyldimethylsilyl chloride 85 a and excess imidazole in DMF at 25 °C furnishes the imidazole derivative 1223a in 70% yield, whereas the phenyl derivative 1222b affords, besides 47% of 1223b , the cyclized product 1224 in 24% yield and 94 a and imidazole hydrochloride [34] (Scheme 8.14). Reaction of 1225 with N-(trimethylsilyl)imidazole 1219 at 170°C affords 1226 in 50% yield [35]. 

The combined extracts are dried over magnesium sulfate, filtered and to the filtrate is added 2-propanol previously saturated with gaseous hydrogen chloride. The precipitated salt is filtered off, dried for 2 days at 60°C, to yield dl-l-(l-phenylethyl)-5-(ethoxycarbonyl)imidazole hydrochloride. It has a melting point 142°C to 142.8°C. 

Chemical Name 2-[ [4-(l, 1-Di methylethyl)-2,6-dimethyl phenyl] methyl]-4,5-dihydro-lH-imidazole hydrochloride... 

Thiophosphorsaure-chlorid-diester setzen sich mit Imidazol (1,4-Dioxan, 25°) zu den Imidazoliden um, die nach Abtrennen vom Imidazol-Hydrochlorid mit Wasser in die Imi-dazolium-Salze der Thiophosphorsaure-O,O-diester ubergefiihrt werden5 z.B. ... 

B. 2-( 1,3-Dibenzoyl-4-imidazolin-2-yl)imidazole hydrochloride. 3 Into a 3-L beaker equipped with an air-driven stirrer are successively introduced 150 g (0.335 mol) of dry, unrecrystallized... 

C. 2-, 3-Dibenzoylimidazolidin-2-yl)imidazole hydrochloride.3 A 1000-mL Paar hydrogenation bottle is charged with 38.0 g (0.10 mol) of dry, unrecrystallized 2-(l,3-dibenzoyl-4-imidazolin-... 

Trituration of the residue with dilute hydrochloric acid, and cooling to 0°C, gives the imidazole hydrochloride salts, which are frequently crystalline. The free bases can be obtained by making the salts alkaline with aqueous sodium hydroxide followed by extraction with ether. The ether is removed to give the products (1). Some free bases precipitate from aqueous alkaline solution and need not be extracted. The aininoaldehydes from aspartic and glutamic acids are best distilled at around 1 mmHg pressure to purify them. 

The reagent is prepared by the reaction of thionyl chloride in tetrahydrofurane with 4 equivalents of imidazole the solution, filtered from imidazole hydrochloride. 

Carbonyldiimidazole 599 Imidazole (10 g) is dissolved in anhydrous tetrahydrofuran (120 ml) in a 250-ml flask with a ground neck. Phosgene (2.50 ml) is pipetted into this solution by means of a graduated acid pipette provided with a trap cooled in acetone-carbon dioxide. The precipitated imidazole hydrochloride is collected on a frit with a ground neck, so that water can be excluded. Evaporation of the tetrahydrofuran solution in a vacuum gives the carbonyldiimidazole (90-95%), m.p. 116-118°. 

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