Temporal discrimination

In the dorsal and median raphe nuclei, failed to modify performance in the acquisition of temporal discrimination and memory in a delayed conditional discrimination task in rats (Al-Zahrani et al. 1996) and using a delayed interval bisection task (Al-Zahrani et al. 1997). 

Al-Zahrani SS, Ho MY, Al-Ruwaitea AS, et al Effect of destruction of the 5-hydroxytryptaminergic pathways on the acquisition of temporal discrimination and memory for duration in a delayed conditional discrimination task. Psychopharmacology 123 103-110, 1996... 

Deiters, E., Song, B., Chauvin, A.S., et al. (2009) Luminescent bimetallic lanthanide bioprobes for cellular imaging with excitation in the visible-Ught range. Chemistry —A European Journal, 15, 885—900. Charbonniere, L.J., Weibel, N., Estoumes, C., et al. (2004) Spatial and temporal discrimination of siUca particles functionalized with luminescent lanthanide markers using time-resolved luminescence microscopy. New Journal of Chemistry, 28, 777—781. 

While spectral discrimination is the most common method of base caUing used, temporal discrimination offers several advantages (1) The Hfetime of the fluoro-phore is independent of concentration, (2) fluorescence Hfetime values may be determined with more accuracy than fluorescence intensity, (3) temporal measurements are not hindered by broad emission profiles, and (4) a single detection channel may be used. Soper has developed a method using heavy atom modified NIR dyes for base calling in DNA sequencing using temporal discrimination [74]. One... 

Flanagan, J.H., Jr., Owens, C.V., Romero, S.E., Waddell, E., Kahn, S.H., Hammer, R.P., and Soper, S.A., Near-infrared heavy-atom-modified fluorescent dyes for base-caUing in DNA-sequencing applications using temporal discrimination, Anal. Chem., 70, 2676, 1998. 

Charbonniere L. J., N. Weibel, C. Estoumes, C. Leuvrey, R. F. Ziessel. Spatial and temporal discrimination of silica particles functionalised with luminescent lanthanide markers using time-resolved luminescence microscopyy, New J. Chem., 28, 111-1 1 (2004). 

Among optical sensors, those based on fluorescence are of major interest because of their ability to use spectral and temporal information multi-wavelength measurements allow simultaneous detection of two or more analytes, and discrimination between analytes is possible by time-resolved measurements. Multiplex capabilities represent the main advantage of such sensors compared to electrochemical devices. 

Stolerman IP, Garcha HS (1989) Temporal factors in drag discrimination experiments with nicotine. J Psychopharmacol 3 88-97... 

Because the binding of TNT and DNT is dependent on the structure of the polymer film, using two different polymers in series can assist in further discriminating the two similar analytes. This device architecture is shown in Figure 12. Figure 13 illustrates this effect in comparing the temporal response of TNT vapor... 

Humans and insects can discriminate enantiomers of the same compound (Friedman and Miller, 1971 Russell and Hills, 1971) (Table 2.1). Blacktailed deer Odocoileus hemionus columhianus) discriminate between the two geometric isomers and somewhat between the enantiomers of the deer lactone (Fig. 2.2) (Brownlee eta/., 1969 Muller-Schwarzeeta/., 1976,1978a). Young male Asian elephants have more (+) than (-) enantiomer of frontalin in their temporal secretion. Their secretion and(+)-frontalin affect conspecifics little. However, the nearly recemic enantiomer mix from mature bulls attracts ovulating females and repels males (Greenwood etal., 2005)... 

The inferior longitudinal fasciculus follows the ventral stream and involves a pathway conjoining the primary visual cortex with the inferior temporal cortex. It is believed to be involved in object identification by integrating feature analysis with object discrimination. Single cell recordings from area V4 of the extrastriate cortex during covert orientation of attention reveal an in-... 

Other brain regions are undoubtedly involved in affi-liative behaviors. For example, the ventral temporal area of the cortex appears to be involved in facial discrimination in humans, and abnormalities in the activation of this area during facial discrimination tasks are present in individuals with autism (Schultz et ah, 2000). In rats and other mammals, the olfactory bulb and entorhinal cortex also appear to be involved in affiliative behaviors, including maternal behaviors (Numan, 1994). 

Schultz, R.T., Gauther, L, Klin, A., Fulbright, R.K., Andetson, A.W., Volkmar, F., Skudlarski, P., Lacadie, C., Cohen, D.J., and Gote, J.C. (2000) Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Aspetget syndrome. Arch Gen Psychiatry 57 331—340. 

---