Entorhinal cortex

Kohler, C. Chan-Palay, V. Haglund, L. and Steinbusch, H.W.M. Immunohistochemical localization of serotonin nerve terminals in the lateral entorhinal cortex of the rat Demonstration of two separate patterns of innervation from the midbrain raphe. Anat Embryol 160 121-129, 1980. 

Clapham, J. Kilpatrick, G. J. (1992). Histamine H3 receptors modulate the release of [3H]-acetylcholine from slices of rat entorhinal cortex evidence for the possible existence of H3 receptor subtypes. Br. ]. Pharmacol. 107,... 

Manns, I. D., Mainville, L. 8r Jones, B. E. (2001). Evidence for glutamate, in addition to acetylcholine and GABA, neurotransmitter synthesis in basal forebrain neurons projecting to the entorhinal cortex. Neuroscience 107, 249-63. 

Hippocampus, amygdala, septum entorhinal cortex, hypothalamus, raphe nuclei... 

Hippocampus, entorhinal cortex, amygdala, nucleus, accumbens, solitary tract nerve, trigeminal nerve, motor nucleus of the dorsal vagal nerve, area postrema, spinal cord... 

Collins, R. C., Tearse, R. G. and Lothman, E. W. Functional anatomy of limbic seizures focal discharges from medial entorhinal cortex in rat. Brain Res. 280 25-40,1983. 

Neuroanatomical and neuropathological basis of Alzheimer s disease Histological features of Alzheimer s disease include neuritic plaques and neurofibrillary tangles (Boiler and Duyckaerts 1997). Neuritic plaques are composed of extracellular deposits of j8-amyloid protein and apolipoprotein E and are found primarily in neocortex. j8-amyloid is derived from an amyloid precursor protein, and is suspected to be a chief causal factor in Alzheimer s disease pathology (Samuel et al. 1997). Neurofibrillary tangles are clusters of protein fibers found in the cell body and composed of tau protein, which normally serves as a cytoskeletal element. Neurofibrillary tangles progress from entorhinal cortex to hippocampus, and then to neocortical areas. 

Degroot A, Parent M. 2001. Infusions of physostigmine into the hippocampus or the entorhinal cortex attenuate avoidance retention deficits produced by intra-septal infusions of the GABA agonist muscimol. Brain Research 920(1-2) 10-18. 

Kar S, Baccichet A, Quirion R, Poirier J. 1993b. Entorhinal cortex lesion induces differential responses in [ I] insulinlike growth factor I, [ I] insulin-like growth factor II and [ I] insulin receptor binding sites in the rat hippocampal formation. Neuroscience 55 69-80. 

Figure 7.3. The inhibition of [ H]GR65630 binding to homogenates of rat entorhinal cortex by ICS 205-930 (O), ondansetron (A), MDL 72222 (U) and 5-HT (V). Results are the mean + S.E.M. of at least three separate determinations. Experiments were performed as described...

HT3 receptor agonists have been shown to enhance the release of endogenous dopamine from striatal slices [14] and to reduce acetylcholine release from sections of rat entorhinal cortex [15]. Furthermore, there are several electrophysiological techniques using a variety of neurones, including those in the gut [25] and primary cultures of brain tissue [26] which respond to 5-HT3 agonist stimulation. 

Rose JE, Levin ED (1991) Inter-relationships between conditioned and primary reinforcement in the maintenance of cigarette smoking. Br J Addict 86(5) 605-609 Rosecrans JA (1971) Elfects of nicotine on brain area 5-hydroxytryptamine function in male and female rats separated for differences of activity. Eur J Pharmacol 16(1) 123-127 Rosecrans JA (1972) Brain area nicotine levels in male and female rats with different levels of spontaneous activity. Neuropharmacology ll(6) 863-870 Rosecrans JA, Schechter MD (1972) Brain area nicotine levels in male and female rats of two strains. Arch Int Pharmacodyn Ther 196(l) 46-54 Saigusa T, Takada K, et al (1997) Dopamine efflux in the rat nucleus accumbens evoked by dopamine receptor stimulation in the entorhinal cortex is modulated by oestradiol and progesterone. Synapse 25(1) 37 3... 

Figure 1. A. SimpMed diagram of the rodent hippocampal formation illustrating the major glutamatergic circuitry. The principal neuronal helds granule cells (GC) of the dentate gyrus and pyramidal cells of CAl and CA3 in Ammon s horn are shown. The main excitatory connections are also indicated the perforant path from entorhinal cortex to the granule cells, from there the mossy hbre (mf) axonal projections to CA3 and then the Schaffer collaterals (Sch) from CA3 to ipsilateral CAl and commissural (Comm) to contralateral CAl cells. Evoked responses in (B) were obtained by stimulating the afferent pathway from entorhinal cortex, the medial perforant path (Med), and recording the granule cell (GC) response in the hilus of the dentate gyrus.

Forehmin frontal cortex olfactory nucleus nucleus accumbens septal area amygdala hypothalamus entorhinal cortex caudate nucleus entopeduncular nucleus hippocampus ventral and medial thalamus median forebrain bundle dorsal noradrenergic bundle... 

Figure 1. Dopamine D2 receptor binding in human temporal cortex from a patient with dementia with Lewy bodies and matched control. Numbers refer to cortical Brod-mann areas and Ent cx = entorhinal cortex.

Figure 2. A. Distribution of the serotonin receptor, 5-HT2 subtype which binds the indoleamine hallucinogens, in human temporal cortex as indicated by the binding of radiolabelled ketanserin. While the receptor is relatively sparse in the hippocampal area and entorhinal cortex on the top right, it is concentrated in the temporal association cortex including the area concerned with visual association.

---