Tartrazine allergic reactions

Both the European Union and the FDA have pubhshed lists that are subject to regular review. The greatest concern has been expressed over the use of azodye colours as certain individuals can demonstrate an allergic reaction to some of these. Allergic reactions have been reported most frequently for sunset yellow (E110, FD C yellow no. 6) and tartrazine (E102, FD C yellow no. 5). 

There are many scientific reports (although typically not recent ones) on tartra-zine, azo, and non-azo dyes, which suggest that these colorings can cause adverse reactions (albeit not so frequently < 1%) (Nettis et al. 2003). There have been rare cases of urticaria or asthma developed after ingesting tartrazine or other azo dyes, but the relationship between the cause and illness symptoms is generally overestimated, as it is based on earlier studies (Nettis et al. 2003, Stevenson 2008, van Bever et al. 1989). It has also been identified that patent blue and carmine dye induced severe allergic reactions (Makinen-Kiljunen and Haahtela 2008). 

Tablets contain tartrazine, which may cause allergic reactions, particularly in patients allergic to aspirin... 

Tofranil-PM(r) (imipramine pamoate) 100-and 125-mg capsules contain the dye tartrazine (FD C yellow No. 5), which may cause allergic reactions in some patients this reaction is more likely in patients with sensitivity to aspirin... 

At present there is insufficient reliable scientific data on the adverse effects of food additives in humans but there is much public concern and many anecdotal reports of problems relating to food additives, particularly allergic reactions. The extent of intolerance to food additives in the population at large is, however, only around 3 in 10,000 or, to be more precise, 0.026 per cent). Most of the data available refers to patients who have symptoms such as skin rashes (urticaria). Some of the studies carried out have, however, highlighted certain effects and the same food additives appear to feature in the reports tartrazine and benzoic acid are the most common offenders, especially in relation to h5q>eractivity in children. There may also be cross-reactivity, where an additive causes an effect in a person who has been sensitized by another additive. This can occur between additives and naturally occurring food constituents, for... 

However, a range of foreign proteins, which are potential antigens, are present in the diet and are absorbed from the gastrointestinal tract. The immune systems of most individuals become tolerant via a regulatory system which prevents adverse reactions to food constituents and additives. However some individuals seem predisposed to allergic diseases and do not become tolerant and so may develop adverse reactions to dietary constituents. It is possible that the interaction of a breakdown product of tartrazine with a protein in the body could be sufficient to cause an allergic reaction in some sensitive individuals. 

F. Some oral haloperidol tablets contain tartrazine dye, v ich may precipitate allergic reactions in susceptible patients. 

Hydrocodone bitartrate is absolutely contraindicated in patients with known hypersensitivity reactions to hydrocodone. Commercial preparations may also contain sulfite compounds that can produce allergic reactions, including bronchospasm and anaphylaxis, in certain susceptible individuals, particularly asthmatic patients. In addition, the dye tartrazine is present in one preparation of hydrocodone bitartrate, combined with chlorpheniramine maleate and phenylephrine hydrochloride, that is used as an antitussive and expectorant agent (Vanex). Also known as FD C yellow No. 5, tartrazine can cause asthmatic and other allergic reactions in some susceptible patients, especially those with aspirin sensitivities. 

In addition to the foods themselves, some food additives may cause allergic reactions. An example is tartrazine, an azo dye, which is added to many foods and soft drinks, and which may cause urticaria and asthma. The food preservatives sulphur dioxide and sodium benzoate, present in many orange drinks, have also been responsible for attacks of asthma. 

The thiazide diuretics are contraindicated in patients with known hypersensitivity to the thiazides or related diuretics, electrolyte imbalances, renal decompensation, hepatic coma, or anuria. A cross-sensitivity reaction may occur with the thiazides and sulfonamides. Some of the thiazide diuretics contain tartrazine, which may cause allergic-type reactions or bronchial asthma in individuals sensitive to tartrazine. 

Tartrazine/suifite sensitivity Some of these products contain tartrazine or sulfites, which may cause allergic-type reactions. 

Peripheral neuritis Peripheral neuritis evidenced by paresthesias, numbness, and tingling, has been observed. Add pyridoxine to the regimen if symptoms develop. Hematologic effects Blood dyscrasias consisting of reduction in hemoglobin and red cell count, leukopenia, agranulocytosis, and purpura have been reported. If such abnormalities develop, discontinue therapy. Periodic blood counts are advised. Tartrazine sensitivity Some of these products contain tartrazine, which may cause allergic-type reactions in susceptible individuals. Tartrazine sensitivity is frequently seen in patients who also have aspirin hypersensitivity. 

Allergic-type reaction may occur in those with tartrazine sensitivity. 

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