Tandem mass spectrometry Bioanalysis

Shou, W. Z. Chen, Y. L. Eerkes, A. Tang, Y. Q. Magis, L. et al. Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns. Rapid Commun Mass Spectrom 2002, 16, 1613-1621. 

Wu, S.T., Schoener, D., and Jemal, M., Plasma phospholipids implicated in the matrix effect observed in liquid chromatography/tandem mass spectrometry bioanalysis Evaluation of the use of colloidal silica in combination with divalent or trivalent cations for the selective removal of phospholipids from plasma, Rapid Commun. Mass Spectrom., 22(18), 2873, 2008. 

Hsieh S. et al., 2004. Increased throughput of parallel online extraction liquid chromatography /electrospray ionization tandem mass spectrometry system for GLP quantitative bioanalysis in drug development. Rapid Commun Mass Spectrom 18 285. 

Huang M.Q. et al., 2006. Increased productivity in quantitative bioanalysis using a monohth column coupled with high-flow direct-injection hquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 20 1709. 

Jemal M., Xia Y., and Whigan D.B., 1998. The use of high-flow high performance liquid chromatography coupled with positive and negative ion electrospray tandem mass spectrometry for quantitative bioanalysis via direct injection of the plasma/serum samples. Rapid Commun Mass Spectrom 12 1389. 

Jemal, M. Ouyang, Z. Enhanced resolution triple-quadrupole mass spectrometry for fast quantitative bioanalysis using liquid chromatography/tandem mass spectrometry investigations of parameters that affect ruggedness. Rapid Commun Mass Spectrom 2003, 17, 24-38. 

C. L. Olah, T. V. et al. High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis ... 

Deng, Y Wu, J. T Lloyd, T. L Chi, C. L Olah, T. V., and Unger, S. E. (2002). High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis 30 seconds per sample from plasma. Rapid Commun. Mass Spectrom. 16 1116-1123. 

Larger, P. J., Breda, M., Lraier, D., Hughes, H., and James, C. A. (2005). Ion-suppression effects in liquid chromatography-tandem mass spectrometry due to a formulation agent, a case study in drug discovery bioanalysis. J. Pharm. Biomed. Anal. 39 206-216. 

Dethy, J. M., Ackermann, B. L., Delatour, C., Henion, J. D., and Schultz, G. A. (2003a). Demonstration of direct bioanalysis of drugs in plasma using nanoelectrospray infusion from a silicon chip coupled with tandem mass spectrometry. Anal. Chem. 75 805-811. 

Allanson, J. P. Biddlecombe, R. A. Jones, A. E. Pleasance, S. 1996. The use of automated solid phase extraction in the 96 well format for high throughput bioanalysis using liquid chromatography coupled to tandem mass spectrometry. Rapid Commun. Mass Spectrom., 10,811-816. 

Deng P, Chen X, Zhang G, Zhong D (2010) Bioanalysis of an oligonucleotide and its metabolites by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 52 571-579... 

Zhang G, Lin J, Srinivasan K, Kavetskaia O, Duncan JN (2007) Strategies for bioanalysis of an oligonucleotide class macromolecule from rat plasma using liquid chromatography-tandem mass spectrometry. Anal Chem 79(9) 3416-3424... 

Li F, Hsieh Y, Kang L, Sondey C, Lachowicz J, Korfmacher W (2009) MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolites in rat brain sections. Bioanalysis l(2) 299-307. doi 10.4155/BIO.09.27... 

Quantitation of drags and their metabolites in biological matrices currently is one of the most important applications of LC-MS. This can be attributed to the greatly enhanced selectivity and reliability of the analysis, as compared to LC-UV. Selective reaction monitoring (SRM) in tandem mass spectrometry (MS-MS) has become the method-of-choice in quantitative bioanalysis. Ample examples are described in literatnre. Even a larger number of successful examples are hidden in the archives of pharmaceutical companies and contract research organizations. 

Dethy, J.M. Ackermann, B.L. Delatour, C. Henion, J.D. Schultz, G.A. "Demonstration of Direct Bioanalysis of Drugs in Plasma Using Nanoelectrospray Infusion from a Silicon Chip Coupled with Tandem Mass Spectrometry, Anal. Chem. 75, 805-811 (2003). 

Deng, Y Wu, J.-T, Lloyd, T.L. Chi, C.L. Olah, TV. Unger, S.E. Highspeed Gradient Parallel Liquid Chromatography/Tandem Mass Spectrometry with Fully Automated Sample Preparation for Bioanalysis 30 Seconds per Sample from Plasma, Rapid Commun. Mass Spectrom. 16, 1116-1123 (2002). 

Jemal M. Ouyang, Z. Enhanced Resolution Triple-Quadrupole Mass Spectrometry for Fast Quantitative Bioanalysis Using Liquid Chromatography/Tandem Mass Spectrometry Investigations of Parameters That Affect Ruggedness, Rapid Commun. Mass Spectrom. 17,24-38 (2003). 

Biddlecombe, R.A. Benevides, C. Pleasance, S. A Clinical Trial on a Plate The Potential of 384-Well Format Solid Phase Extraction for High-Throughput Bioanalysis Using Liquid Chromatography/Tandem Mass Spectrometry, Rapid Commun. Mass Spectrom. 15, 33 0 (2001). 

Jemal, M. Qing, Y. Whigan, D.B. The Use of High-Flow High Performance Liquid Chromatography Coupled with Positive and Negative Ion Electrospray Tandem Mass Spectrometry for Quantitative Bioanalysis via Direct Injection of the Plasma/Serum Samples, Rapid Commun. Mass Spectrom. 12, 1389-1399 (1998). 

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