Tablet enteric coating

Tablets, enteric-coated 64 mg elemental magnesium (as chloride hexahydrate) otc) Siow-Mag (Shire)...

Tablets, enteric-coated 325 mg (ofc) Various, Ecotrin Tablets and Caplets (GlaxoSmithKline), Regular Strength Bayer Enteric Coated Caplets (Sterling Health)... 

Aspirin is available as capsules, tablets, enteric-coated tablets (Ecotrin), timed-release tablets (ZORprin), buffered tablets Ascriptin, Bufferin), and as rectal suppositories. Sodium salicylate is available genericaUy. Other salicylates include choline salicylate (Arthropan), choline magnesium trisalicylate (Trilisate), and magnesium salicylate Momentum). 

Tablets [Enteric-Coated [Dynabac, Dynabac D -Pak ) 250 mg Indications and Dosages ... 

Tablets, enteric-coated See Enteric-coated doses.

Aabakken L, Bjornbeth BA, Hofstad B, Olaussen B, Larsen S, Osnes M. Comparison of the gastrointestinal side effects of naproxen formulated as plain tablets, enteric-coated tablets, or enteric-coated granules in capsules. Scand J Gastroenterol Suppl 1989 163 65-73. 

Luce GT. Disintegration of tablets enteric coated with CAP. Manuf Chem Aerosol News 1978 49(7) 50, 52, 67. 

Enteric coating is also used for repeat-action tablets, which contain an enteric-coated core tablet and a sugar or film-coated second dose, permitting the adininistration of two doses simultaneously. The core dose is released several hours after the initial, outer dose. 

Uses. Aspirin has analgesic, antiinflammatory, and antipyretic activity. It is used for the reHef of less severe types of pain, such as headache, neuritis, acute and chronic rheumatoid arthritis, and toothache. Aspirin can be purchased in a variety of OTC and prescription dosage forms made and formulated by many companies. Tablets, ie, buffered, plain, or enteric-coated, are the most familiar in the United States, but other forms such as powder and effervescent formulations are of considerable importance in other parts of the world. 

Delivery systems that respond to changes in pH have been known to the pharmaceutical industry for more than a century. The pH-sensitive enteric coating is probably the oldest controUed-release technology. Unna introduced an enteric tablet coating based on keratin in 1884 (108). Enteric coatings are used primarily to protect the gastric mucosa from local irritation or to ensure that tablets do not dissolve until they reach the intestine. 

DIGESTIVE ENZYMES. When digestive enzymes are given in capsule or enteric-coated tablet form, the nurse... 

If the tablet has a coating (enteric-coated tablets), swallow it whole. Do not chew or crush the tablet. 

Neural networks have also been used in Slovenia, to model the release characteristics of diclofenac [52] in China, to study release of nifedipine and nomodipine [53] and in Yugoslavia to model the release of aspirin [54], More recently, work in this area has been extended to model osmotic pumps in China [55] and enteric coated tablets in Ireland [56],... 

Turkoglu M, Varol H, Celikok M. Tableting and stability evaluation of enteric-coated omeprazole pellets. Eur J Pharm Biopharm 2004 57 277-86. 

Shark cartilage 3 tablets by mouth daily Enteric-coated aspirin 81 mg by mouth daily Ginseng 2 tablets by mouth daily... 

Comparable daily doses of PPIs are omeprazole 20 mg = esomeprazole 20 mg = lansoprazole 30 mg = rabeprazole 20 mg = pantoprazole 40 mg. The PPIs degrade in acidic environments and are therefore formulated in delayed-release capsules or tablets.16 Lansoprazole, esomeprazole, and omeprazole contain enteric-coated (pH-sensitive) granules in a capsule form. For patients unable to swallow the capsule or in pediatric patients, the contents of the capsule can be mixed in applesauce or placed in orange juice. If a patient has a nasogastric tube, the contents of an omeprazole capsule can be... 

Sulfasalazine Azulfidine Azulfidine Entabs Sulfazine Sulfazine EC Immediate-release or enteric-coated tablets 500 mg 2-6 g Colon... 

C, powder encased in a cellulose capsule ECMS, enteric-coated microspheres encased in a cellulose or gelatin capsule ECMT, enteric-coated microtablets encased in a cellulose capsule UCT, uncoated tablet P, powder. 

Non-enteric-coated pancreatic enzyme supplements can be used for initial therapy. The relative dose of amylase, lipase, and protease may be increased until control of pain and fatty diarrhea is achieved or the patient experiences intolerable side effects. If pain and diarrhea control are achieved, the patient can be transitioned to an enteric-coated supplement to maximize compliance. A reasonable example starting regimen is Viokase-8, six tablets with each meal and at bedtime, given with famotidine 20 mg at bedtime. 

Pancreatic enzyme supplements should be taken immediately prior to meals to aid in the digestion and absorption of food. Alternately, patients can supplement their diet with medium chain triglycerides (MCTs) or ingest foods rich in MCTs since they do not require pancreatic enzymes for absorption. An appropriate regimen incorporates the successful doses of each enzyme (amylase, lipase, and protease) from the starting non-enteric-coated regimen. As with the previous example, a patient stabilized on Viokase-8, six tablets with each meal, can be transitioned to Pancrease MT-16 three tablets with meals. The famotidine can then be discontinued. 

Syrup/suspension/ solution Extended-release/ enteric-coated tablets Faster rate of absorption 100% Delayed absorption 60-90% Faster rate of absorption Delayed absorption 89% of the suspension and less than regular-release tablets Unknown NA Faster rate of absorption than tablets Extended-release 90% of intravenous dose. Delayed-release 81-90% of intravenous dose Delayed absorption with delayed-release tablets valproate is rapidlyconverted to VPA in the stomach, then is rapidly and almost completely absorbed from the Gl tract NA NA... 

Mycophenolate mofetil is available in 250 mg capsules and 500 mg tablets, an oral suspension (100 mg/mlL, in cherry syrup), and an injectable.11 Usual doses of mycophenolate mofetil range from 1000 to 3000 mg/day in two to four divided doses. The conversion between oral and IV mycophenolate mofetil is 1 1. Enteric-coated mycophenolic acid is available in 180 and 360 mg tablets. For conversion between mycophenolate mofetil and enteric-coated MPA, 1000 mg mycophenolate mofetil is equivalent to 720 mg enteric-coated MPA.26,29 The recommended starting dose of enteric-coated mycophenolic acid is 720 mg given twice daily.11 It appears that conversion of mycophenolate mofetil to enteric-coated mycophenolic acid is safe, but more studies are needed to determine the exact role of enteric-coated MPA in the immunosuppressive armamentarium. Mycophenolic acid trough concentrations can be monitored, but they are not recommended routinely. 

A drug should always be ingested with a cup of water ( 8 oz) to insure easy transit down the esophagus and to provide fluid for disintegration and dissolution. Whether or not the drug should be taken on an empty stomach (e.g., enteric-coated tablets) or with food will depend upon the specific drug as noted above. 

RH Blythe, GM Grass, DR MacDonnell. The formulation and evaluation of enteric coated aspirin tablets. Am J Pharm 131 206-216, 1959. 

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