Enteric-coated aspirin

Uses. Aspirin has analgesic, antiinflammatory, and antipyretic activity. It is used for the reHef of less severe types of pain, such as headache, neuritis, acute and chronic rheumatoid arthritis, and toothache. Aspirin can be purchased in a variety of OTC and prescription dosage forms made and formulated by many companies. Tablets, ie, buffered, plain, or enteric-coated, are the most familiar in the United States, but other forms such as powder and effervescent formulations are of considerable importance in other parts of the world. 

Neural networks have also been used in Slovenia, to model the release characteristics of diclofenac [52] in China, to study release of nifedipine and nomodipine [53] and in Yugoslavia to model the release of aspirin [54], More recently, work in this area has been extended to model osmotic pumps in China [55] and enteric coated tablets in Ireland [56],... 

Shark cartilage 3 tablets by mouth daily Enteric-coated aspirin 81 mg by mouth daily Ginseng 2 tablets by mouth daily... 

RH Blythe, GM Grass, DR MacDonnell. The formulation and evaluation of enteric coated aspirin tablets. Am J Pharm 131 206-216, 1959. 

In patients experiencing an ACS, non-enteric-coated aspirin, 162 to 325 mg, should be chewed and swallowed as soon as possible after the onset of symptoms or immediately after presentation to the emergency department regardless of the reperfusion strategy being considered. 

Voltarol is a brand-name preparation for diclofenac (NSAID) and modified-release tablets are available in 75 mg and 100 mg strength. Nu-seals is a proprietary preparation of enteric-coated aspirin 75 mg. Fentanyl, co-codamol and Suboxone (buprenorphine and naloxone) consist of opioid drugs. 

Although fecal blood loss is less with enteric coated aspirin than with uncoated, give enteric coated aspirin with caution to patients with Gl distress, ulcer, or bleeding problems. 

Aspirin is available as capsules, tablets, enteric-coated tablets (Ecotrin), timed-release tablets (ZORprin), buffered tablets Ascriptin, Bufferin), and as rectal suppositories. Sodium salicylate is available genericaUy. Other salicylates include choline salicylate (Arthropan), choline magnesium trisalicylate (Trilisate), and magnesium salicylate Momentum). 

Substances which form masses Aspirin, iron, lithium, enteric-coated tablets, meprobamate. 

A 75-year-old man taking insulin about 40 U/day was given metformin 500 mg bd (104). He also used enteric-coated aspirin, diltiazem XR, ibuprofen, and lovastatin. Two months later his liver enzymes were raised, but he felt well. Hepatitis antibodies were negative. After withdrawal of metformin his liver enzymes became normal. He agreed to restart metformin. His liver enzymes remained normal, but he finally preferred insulin monotherapy. 

Mojaverian, P., Rocci, M. L., Conner, D. P., et al. Effect of food on the absorption of enteric-coated aspirin Correlation with gastric residence time. Clin. Pharmacol. Ther. 41 11-17, 1987. 

The risk of embolism associated with mechanical heart valves is 2 to 6% per patient per year despite anticoagulation and is highest with valves in the mitral position. Warfarin therapy (INR 2.5 to 3.5) is recommended in these patients. The addition of enteric-coated aspirin (100 mg/d) to warfarin (INR 3.0 to 4.5) in high-risk patients (preoperative atrial fibrillation, coronary artery disease, history of thromboembolism) with mechanical valves decreases the incidence of systemic embolism and death from vascular causes (1.9 vs. 8.5% per year), but increases the risk of bleeding. 

The relationship between gastric residence time (GRT) and the variability in aspirin absorption from enteric-coated tablets has also been evaluated with the Heidelberg capsule [59], The study design was a single dose crossover study with men and women, fasted and fed. In addition to pH monitoring, plasma concentrations of salicylic acid and salicyluric acid in plasma and urine were measured. GRT was significantly delayed in the fed state, and women had longer GRT compared with men. 

Aspirin, especially when used chronically in geriatric populations, is known for its side effects of GI discomfort and bleeding. Therefore, serum salicylate levels with regular and enteric-coated aspirin were compared in volunteers in a chronic disease hospital and residential home for the elderly [42], It was found that there was no significant difference between the blood levels reached with conventional... 

J. J. Qrozco-Alcala, J. Baum, Regular and enteric coated aspirin a revolution, Arthritis Rheum 22(9) 1034-1037 (1979). 

Maree AO, Curtin RJ, Dooley M, et al, Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease. J Am Coll Cardiol 2005 46 1258-1263,... 

Aspirin is commercially available in numerous formulations (Table 7-1). It is compounded as a tablet, an enteric-coated tablet, a controlled-release tablet, and as a suppository. Enteric-coated aspirin, which decreases GI tract irritation, is recommended for chronic use but is rarely required for the treatment of acute ocular pain, which usually resolves over several days. Likewise, controlled-release aspirin, because of its relatively long onset of action, is not recommended for treatment of acute ocular pain. 

Rao GHR, Radha E, White IG. Enteric coated aspirin, platdd cydooxygenase activity and function. Prost Leukot Med 1984 13 3-12... 

Although the use of enteric-coated aspirin can reduce its direct adverse effect on the stomach (SEDA-10, 72), it could in principle transfer these to some extent to the intestine modified-release NSAIDs have sometimes caused intestinal perforation. 

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