T cells signal transduction

F.A. Etzkorn, L.A. Stolz, Z.Y. Chang, C.T. Walsh, Role of the cyclosporin-A-cyclophilin complex, FK506-FK506-binding protein complex and calcineurin in the inhibition of T-cell signal transduction, Curr. Opin. Struct. Biol. 3 (1993) 929-933. 

Horrocks, L. A. and Farooqui, A. A. NMDA receptor-stimulated release of arachidonic acid mechanisms for the Bazan effect. In Municio, A. M. and Miras-Portugal, M. T. (eds), Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease. New York Plenum Press, 1994, pp. 113-128. 

Bredholt T, Ersvaer E, Erikstein BS, Sulen A, Reikvam H, Aarstad HJ, et al. Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-Uke cathinone, cathine, or norephedrine. BMC Pharmacol Toxicol 2013 14 35. 

Yamato, M., Okuhara, M., Karikusa, F., Kikuchi, A., Sakurai, Y, Okano, T. (1999). Signal transduction and cytoskeletal reorganization are required for cell detachment from cell culture surfaces grafted with a temperature-responsive polymer. Journal of Biomedical Materials Research, 44, 44—52. 

Muto A, Fitzgerald TN, Pimiento JM, Maloney SP, Teso D, Paszkowiak JJ, Westvik TS, Kudo FA, Nishibe T, Dardik A. Smooth muscle cell signal transduction implications of vascular biology for vascular surgeons. /. Vase. Surg. 45(Suppl.A) A15-A24,2007. 

Syk and ZAP-70 are early intermediates in the transduction of signals from immune receptors, including the B- and T-cell recqrtors for antigen, activatory natural killer-cell receptors, the mast cell and basophil receptor for IgE, and the widely distributed receptors for the Fc portion of IgG. Immune receptors control checkpoints in lymphocyte development and serve to integrate the responses of innate and acquired immunity. 

Tilton B, Ho L, Oberlin E, et al. Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes. J Exp Med 2000 192(3) 313-324. 

Kijima T, Maulik G, Ma PC, et al. Regulation of cellular proliferation, cytoskeletal function and signal transduction through CXCR4 and c-kit in small cell lung cancer cells. Cancer Res 2002 62 6304-6311. 

Cantrell, D. A., T cell receptor signal transduction pathways, Anna. Rev. Immunol., 14, 259-274, 1996. 

Journet A et al. Towards a human repertoire of monocytic lysosomal proteins. Electrophoresis 2000 21 3411-3419. Soskic V et al. Functional proteomics analysis of signal transduction pathways of the platelet-derived growth factor beta receptor. Biochemistry 1999 38 1757-1764. Thiede B et al. A two dimensional electrophoresis database of a human Jurkat T-cell line. Electrophoresis 2000 21 2713-2720. 

Alteration of membrane structure in immune cells by PUFAs can lead to defective signal transduction and decreased function. PUFA treatment of CD3-activated human T cells results in decreased calcium mobilization, proliferation and IL-2 production... 

Recently, PUFAs were shown to inhibit T cell activation by blocking key signal transduction events, specifically the activation of c-Jun NH2-terminal kinase (JNK) and NF-AT [62], Furthermore, the expression of CD25 (but not CD69) as well as the production of IL-2 and IL-13 (but not IFN-y, IL-4 and IL-10) was significantly reduced in PUFA-treated peripheral blood T cells. In a separate study, Li and colleagues reported... 

Sugawara H, Kurosaki M, Takata M, Kurosaki T 1997 Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J 16 3078-3088... 

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