B cell antigen receptor

The unique domain following the SH4 domain from the N-terminus is a region with considerable variation in the amino acid sequences among different Src family members. This unique domain may be involved in protein-protein interactions. For example, the unique region of Lck is linked to CD4 and CD8, while those of Fyn and Lyn may be associated with the T- and B-cell antigen receptors. 

Sugawara H, Kurosaki M, Takata M, Kurosaki T 1997 Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J 16 3078-3088... 

Saxton, T.M., Oostween, I., BowteU, D., Aebersold R., and Gold, M.R., 1994, B cell antigen receptor crosshnking induces phosphorylation of the ras activators SHC and mSOSl as well as the assembly of complexes containing SHC, Grb2 and SOSl and a 145 kDa tyrosine phosphorylated protein. J. Immunol. 153 623-636. 

Smit, L., de Vries-Smits, A.M.M., Bos, J.L., and Borst, J., 1994, B cell antigen receptor stimulation induces formation ofaShc-Grb2 complex containing multiple tyrosine-phosphorylated proteins. 7. Biol. Chem. 269 20209-20212... 

Yankee, T. M., L. M. Keshvara, S. Sawasdikosol, M. L. Harrison, and R. L. Geahlen. Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain. J Immunol. 163 5827-35.1999. 

The T and B cell antigen receptors are generally composed of several subunits, whereby the frmctions of ligand binding and conduction of the signal are localized on separate subrmits (review Weiss and Littman, 1994 Wilson and Garcia, 1997). 

Intracellular Signal Molecules of the T and B Cell Antigen Receptors... 

The T and B cell antigen receptors do not have any intrinsic protein tyrosine kinase activity. Rather, antigen binding leads to recruitment and activation of protein tyrosine kinases on the cytoplasmic side of the receptor. Probably, coupling of the tyrosine kinase takes place via the ARAM motif directly. 

Marshall, A.J. Krahn, A.K. Ma, K. Duronio, V. Hou, S. TAPPl and TAPP2 are target,s of phosphatidylinositol 3-kinase signaling in B cells sustained plasma membrane recruitment triggered by the B-cell antigen receptor. Mol. Cell. Biol., 22, 5479-5491 (2002)... 

Lau, C. M., C. Broughton, A. S. Tabor, S. Akira, R. A. Flavell, M. J. Mamula, S. R. Christensen, M. J. Shlomchik, G. A. Viglianti, I. R. Rifkin, and A. Marshak-Rothstein. 2005. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. The Journal of experimental medicine 202 1171-1177. 

Gauld SB, Dal Porto JM, Cambier JC (2002) B cell antigen receptor signaling roles in cell development and disease. Science 296 1641-1642... 

Poque, S.L., Kurosaki, T., Bolen, J., Herbst, R., 2000, B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase. J. Immunol. 

R. Zhang, F. W. Alt, L. Davidson, S. H. Orkin, and W. Swat. Defective signalling fhrou the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature, 374 (6521), 470-473, 1995. 

Dal Porto JM, Gauld SB, MerreU KT, MiUs D, Pugh-Bernard AE, Cambier J B cell antigen receptor signaling 101. Mol. Immunol. 50. 2004 41 599-613. 

B cell antigen receptor into lipid rafts reveals a novel step in 54. signaling. J. Immunol. 2001 166 3693-3701. 

B. S. Gaul, M.L. Harrison, R.L. Geahlen, R.A. Burton, and C.B. Post. 2000. Substrate recognition by the Lyn protein-tyrosine kinase NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor Biol. Chem. 275 16174-16182. (PubMed)... 

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