T-lymphocytes developing

Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL. Tec family kinases in T lymphocyte development and function. Annu Rev Immunol 2005 23 549-600. 

Uehara S, Grinberg A, Farber JM, Love PE. A role for CCR9 in T lymphocyte development and migration. J Immunol 2002 168 2811-2819. 

Kerkvliet, N.I., et. al., Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tctrach lorodi bcnzo-p-diox in, J. Immunol., 157, 2310, 1996. 

Briefly suimnai ize the major steps in T lymphocyte development. 

Scollay, R. and Shortman, K. (1985). Identification of early stages of T lymphocyte development in the thymus cortex and medulla. J. Immunol. 134, 3632-3642. 

Possible long-term effects of in utero exposure to immunosuppressants are still seldom investigated. There have been no reports that physical and mental development or renal function are altered. In one study, there were changes in T lymphocyte development in seven children born to mothers who had taken azathioprine or... 

Fig. 5. The role of cytokines in controlling hemopoiesis. Many cytokines play a role in hemopoiesis by stimulating the proliferation and differentiation of cells derived from a pluripotent stem cell population. Early differentiation events take place in the bone marrow, where IL-3, GM-CSF, and IL-7 appear to have important stimulatory roles. TGFp is a negative regulator of early cell differentiation. B-lymphocyte and myeloid cell development continues in the bone marrow while T-lymphocyte development is completed in the thymus. A large number of cytokines have been suggested to act on immature cells to encourage linage specific development.

In addition to the above biological activation processes, which measure either the proliferative response of the particular target cell or the induction of some terminal effector cell function such as antibody formation or cytotoxic T lymphocyte development, IL-2 has also been implicated in the induction of synthetic processes within the target populations. For example, IL-2 has been shown to induce certain subsets of T lymphocyte populations to produce ganuna interferon.15 The significance of this observation may be broader than initially expected in that gamma interferon, which is another glycoprotein lymphokine. 

He, Y. W., and Malek, T. R. (1998). The structure and function of gamma c-dependent cytokines and receptors Regulation of T lymphocyte development and homeostasis. Crit. Rev. Immunol. 18, 503-524. 

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